ArticlePloS one2016
Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Simulated Acute Hypobaric Hypoxia Effects on Cognition in Helicopter Emergency Medical Service Personnel - A Randomized, Controlled, Single-Blind, Crossover Trial.Human factors · 2024Trial
- Review
- Detrimental Effects of Hypoxia on Cognitive Function: Adaptations, Challenges, and Resilience in Andean Populations.Journal of racial and ethnic health disparities · 2025Article
- Respiratory acclimatization and psychomotor performance after rapid ascent and during 3 weeks at 3,100 m-A prospective cohort study in healthy individuals.Frontiers in physiology · 2025Article
- Analysis of Ferritin, Hepcidin, Zinc, C-Reactive Protein and IL-6 Levels in COVID-19 in Patients Living at Different Altitudes in Peru.Biomedicines · 2024Article
- Nitronyl Nitroxide Ameliorates Hypobaric Hypoxia-Induced Cognitive Impairment in Mice by Suppressing the Oxidative Stress, Inflammatory Response and Apoptosis.Neurochemical research · 2024Article
- Contribution of Adenosine in the Physiological Changes and Injuries Secondary to Exposure to Extreme Oxygen Pressure in Healthy Subjects.Biomedicines · 2022Review
- The position of geochemical variables as causal co-factors of diseases of unknown aetiology.SN applied sciences · 2022Review
- Cardiovascular Risk Is Increased in Miner's Chronic Intermittent Hypobaric Hypoxia Exposure From 0 to 2,500 m?Frontiers in physiology · 2021Article
- Influence of Exposure at Different Altitudes on the Executive Function of Plateau Soldiers-Evidence From ERPs and Neural Oscillations.Frontiers in physiology · 2021Article
- A Prospective Evaluation of the Acute Effects of High Altitude on Cognitive and Physiological Functions in Lowlanders.Frontiers in physiology · 2021Article
- TMT-Based Plasma Proteomics Reveals Dyslipidemia Among Lowlanders During Prolonged Stay at High Altitudes.Frontiers in physiology · 2021Article
- The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude.Nutrients · 2020Review
- Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- What are the links between hypoxia and Alzheimer's disease?Neuropsychiatric disease and treatment · 2019Article
- Different Associations of Plasma Biomarkers in Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, and Ischemic Stroke.Journal of clinical neurology (Seoul, Korea) · 2018Article
- Oxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude.Brain and behavior · 2017Article
- Normobaric hypoxia overnight impairs cognitive reaction time.BMC neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypersensitive C-reaction protein (hsCRP) may be a risk factor for cognitive impairment resulting from Alzheimer's disease (AD), stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with cognitive decline due to high altitude exposure. The study was conducted on 100 male military participants who had never been to high altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200) detection, and neurocognitive assessment was performed and total hsCRP, interleukin-6 (IL-6), and homocysteine was estimated at 500 m altitude, 3650 m altitude, 3 day, 1, and 3 month post arriving at the base camp (4400 m), and 1 month after coming back to the 500 m altitude. High altitude increased brain oxygen saturation, prolonged P300 and N200 latencies, injured cognitive functions, and raised plasma hsCRP levels. But they all recovered in varying degrees at 1 and 3 month post arriving at the base camp (4400 m). P300 latencies and hsCRP levels were strongly correlated to cognitive performances. These results suggested that cognitive deterioration occurred during the acute period of exposure to high altitude and may recover probably owning to acclimatization after extended stay at high altitude. Plasma hsCRP is inversely correlated to neurological cognition and it may be a potential biomarker for the prediction of high altitude induced cognitive dysfunction.
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