ReviewExpert review of respiratory medicine2016
A role for airway taste receptor modulation in the treatment of upper respiratory infections.
Review in Expert review of respiratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The structure and function of taste G protein-coupled receptors and their implications in diseases.International journal of oral science · 2026Review
- Variations in basic taste perception and body mass index.Journal of diabetes and metabolic disorders · 2025Article
- The Bittersweet Symphony of COVID-19: Associations betweenLife (Basel, Switzerland) · 2024Article
- Expression of Bitter Taste Receptors and Solitary Chemosensory Cell Markers in the Human Sinonasal Cavity.Chemical senses · 2019Article
- [Taste signal transduction and the role of taste receptors in the regulation of microbial infection].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Review
- Bitter or not? BitterPredict, a tool for predicting taste from chemical structure.Scientific reports · 2017Article
- The Taste of Caffeine.Journal of caffeine research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Taste receptors, initially identified in the oral epithelium, have since been shown to be widely distributed, being found in the upper and lower respiratory tracts, gastrointestinal epithelium, thyroid, and brain. The presence of taste receptors in the nasal epithelium has led to the discovery of their role in innate immunity, defending the paranasal sinuses against pathogens. This article addresses the current paradigm for understanding the role of extraoral taste receptors, specifically the T2R38 bitter taste receptor and the T1R2+3 sweet taste receptor, in respiratory innate defenses and presents evidence for the use of these and other taste receptors as therapeutic targets in the management of chronic rhinosinusitis. Future studies should focus on understanding the polymorphisms of taste receptors beyond T2R38 to fully elucidate their potential therapeutic use and lay the groundwork for their modulation in a clinical setting to decrease the health impact and economic burden of upper respiratory disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.