Evidence map›Paper›PMID 26731649›Full record

ArticlePloS one2016

Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.

Kyriacos Markianos, Emmanuel Bischoff, Christian Mitri, Wamdaogo M Guelbeogo, Awa Gneme, Karin Eiglmeier, Inge Holm, N'Fale Sagnon, Kenneth D Vernick, Michelle M Riehle

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. TheeLife · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyriacos MarkianosProgram in Genomics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, United States of America.
Emmanuel BischoffInstitut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.
Christian MitriInstitut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.
Wamdaogo M GuelbeogoCentre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
Awa GnemeCentre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
Karin EiglmeierInstitut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.
Inge HolmInstitut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.
N'Fale SagnonCentre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou, Burkina Faso.
Kenneth D VernickInstitut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasites and Insect Vectors, CNRS Unit of Hosts, Vectors and Pathogens (URA3012), Paris, 75015, France.
Michelle M RiehleUniversity of Minnesota, Department of Microbiology, Saint Paul, Minnesota, 55108, United States of America.

Funding

Genetic Association Mapping of Malaria Resistance in Anopheles gambiaeR01AI073685 · NIAID · UNIVERSITY OF MINNESOTA · PI VERNICK, KENNETH D · 2007 to 2011
$2.8M
NIAID NIH HHS R01 AI073685
6 · The paper itself

Abstract

Members of the Anopheles gambiae species complex are primary vectors of human malaria in Africa. Population heterogeneities for ecological and behavioral attributes expand and stabilize malaria transmission over space and time, and populations may change in response to vector control, urbanization and other factors. There is a need for approaches to comprehensively describe the structure and characteristics of a sympatric local mosquito population, because incomplete knowledge of vector population composition may hinder control efforts. To this end, we used a genome-wide custom SNP typing array to analyze a population collection from a single geographic region in West Africa. The combination of sample depth (n = 456) and marker density (n = 1536) unambiguously resolved population subgroups, which were also compared for their relative susceptibility to natural genotypes of Plasmodium falciparum malaria. The population subgroups display fluctuating patterns of differentiation or sharing across the genome. Analysis of linkage disequilibrium identified 19 new candidate genes for association with underlying population divergence between sister taxa, A. coluzzii (M-form) and A. gambiae (S-form).

Indexed as

Genetic StructuresPolymorphism, Single NucleotideAnimalsAnophelesBurkina FasoGenetics, PopulationGenome, InsectGenotypeGeographyHumansInsect VectorsLinkage DisequilibriumMalaria, FalciparumPhylogenyPopulation DynamicsSpecies Specificity

Identifiers

PMID26731649
PMCPMC4701492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.