ArticleAnnals of the American Thoracic Society2016
Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Postoperative Neurocognitive Disorders in Cardiac Surgery: Investigating the Role of Intraoperative Hypotension. A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Postoperative cognitive dysfunction and mortality following lung transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Trial
- A Data-Driven Model to Predict Delirium Based on Dynamic Patterns of Clinical Deterioration in Critically Ill Patients.Nursing in critical care · 2025Article
- Association between sleep disorder and delirium in adult patients undergoing cardiac surgery: a retrospective cohort study.BMC anesthesiology · 2025Article
- Article
- The genetic relationship between hypotension and delirium: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Cerebrovascular pulsatility indicates preoperative subcortical cognitive impairment and an increased risk for postoperative delirium in elderly patients undergoing elective spine surgery.Frontiers in medicine · 2024Article
- Perioperative cognition in association with malnutrition and frailty: a narrative review.Frontiers in neuroscience · 2023Review
- The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.Current transplantation reports · 2022Article
- Non-pulmonary complications after lung transplantation: Part I.Indian journal of thoracic and cardiovascular surgery · 2022Review
- Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial.Frontiers in medicine · 2022Article
- Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials.Frontiers in surgery · 2022Review
- Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Delirium Among Adults Undergoing Solid Organ Transplantation.Current transplantation reports · 2021Article
- Article
- Clinical and Neuroimaging Correlates of Post-Transplant Delirium.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Article
- Medically Induced Exacerbation of PTSD Following Lung Transplantation: A Case Series.Journal of clinical psychology in medical settings · 2020Article
- Incidence, risk factors, and clinical implications of post-operative delirium in lung transplant recipients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Neurological Sequelae and Clinical Outcomes After Lung Transplantation.Transplantation direct · 2018Article
- Delirium after lung transplantation: Association with recipient characteristics, hospital resource utilization, and mortality.Clinical transplantation · 2017Article
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7 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleDelirium is common following lung transplant and is associated with poorer clinical outcomes. The extent to which intraoperative hemodynamic alterations may contribute to postoperative delirium among lung transplant recipients has not been examined.
objectivesTo examine the impact of intraoperative hemodynamic changes on neurobehavioral outcomes among lung transplant recipients.
methodsIntraoperative hemodynamic function during lung transplant was assessed in a consecutive series of patients between March and November 2013. Intraoperative cerebral perfusion pressure was assessed every minute in all patients. Following lung transplant, patients were monitored for the presence and severity of delirium using the Confusion Assessment Method and the Delirium Rating Scale until hospital discharge. MEASUREMENTS AND MAIN
resultsSixty-three patients received lung transplants, of whom 23 (37%) subsequently developed delirium. Lower cerebral perfusion pressure was associated with increased risk of delirium (odds ratio [OR], 2.08 per 10-mm Hg decrease; 95% confidence interval [CI], 1.02-4.24; P = 0.043), longer duration of delirium (OR, 1.7 d longer per 10-mm Hg decrease; 95% CI, 1.1-2.7; P = 0.022), and greater delirium severity (b = -0.81; 95% CI, -1.47 to -0.15; P = 0.017).
conclusionsPoorer cerebral perfusion pressure during lung transplant is associated with greater risk for delirium following transplant, as well as greater duration and severity of delirium, independent of demographic and medical predictors.
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