ArticleACS applied materials & interfaces2016
Sundew-Inspired Adhesive Hydrogels Combined with Adipose-Derived Stem Cells for Wound Healing.
Article in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology.Micromachines · 2025Review
- Bacteria-activated macrophage membrane coated ROS-responsive nanoparticle for targeted delivery of antibiotics to infected wounds.Journal of nanobiotechnology · 2024Article
- Review
- Polysaccharide-based hydrogel enriched by epidermal growth factor peptide fragment for improving the wound healing process.Heliyon · 2023Article
- Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.Advanced drug delivery reviews · 2023Review
- Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023Review
- Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development.Bioactive materials · 2022Article
- Gum Arabic protects the rat heart from ischemia/reperfusion injury through anti-inflammatory and antioxidant pathways.Scientific reports · 2022Article
- Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoSBioactive materials · 2022Article
- Advances of hydrogel combined with stem cells in promoting chronic wound healing.Frontiers in chemistry · 2022Review
- 3D bioprinted mesenchymal stromal cells in skin wound repair.Frontiers in surgery · 2022Review
- Tissue Adhesives: From Research to Clinical Translation.Nano today · 2021Article
- A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.Oxidative medicine and cellular longevity · 2021Article
- Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry.Nature communications · 2019Article
- Hydrogels and Their Applications in Targeted Drug Delivery.Molecules (Basel, Switzerland) · 2019Review
- Wound healing and fibrosis: current stem cell therapies.Transfusion · 2019Article
- Current Trends of Nanobiosensors for Point-of-Care Diagnostics.Journal of analytical methods in chemistry · 2019Review
- Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.Advanced drug delivery reviews · 2018Review
- Current development of biodegradable polymeric materials for biomedical applications.Drug design, development and therapy · 2018Review
- Electrical signals triggered controllable formation of calcium-alginate film for wound treatment.Journal of materials science. Materials in medicine · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
The potential to harness the unique physical, chemical, and biological properties of the sundew (Drosera) plant's adhesive hydrogels has long intrigued researchers searching for novel wound-healing applications. However, the ability to collect sufficient quantities of the sundew plant's adhesive hydrogels is problematic and has eclipsed their therapeutic promise. Inspired by these natural hydrogels, we asked if sundew-inspired adhesive hydrogels could overcome the drawbacks associated with natural sundew hydrogels and be used in combination with stem-cell-based therapy to enhance wound-healing therapeutics. Using a bioinspired approach, we synthesized adhesive hydrogels comprised of sodium alginate, gum arabic, and calcium ions to mimic the properties of the natural sundew-derived adhesive hydrogels. We then characterized and showed that these sundew-inspired hydrogels promote wound healing through their superior adhesive strength, nanostructure, and resistance to shearing when compared to other hydrogels in vitro. In vivo, sundew-inspired hydrogels promoted a "suturing" effect to wound sites, which was demonstrated by enhanced wound closure following topical application of the hydrogels. In combination with mouse adipose-derived stem cells (ADSCs) and compared to other therapeutic biomaterials, the sundew-inspired hydrogels demonstrated superior wound-healing capabilities. Collectively, our studies show that sundew-inspired hydrogels contain ideal properties that promote wound healing and suggest that sundew-inspired-ADSCs combination therapy is an efficacious approach for treating wounds without eliciting noticeable toxicity or inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.