ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016
Risk of Colorectal Cancer After Solid Organ Transplantation in the United States.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- De novo colorectal cancer after kidney transplantation: a systematic review and meta-analysis.British journal of cancer · 2025Pooled it
- Cancer risk in people living with HIV and solid organ transplant recipients: a systematic review and meta-analysis.The Lancet. Oncology · 2024Pooled it
- Cancer risk in heart or lung transplant recipients: A comprehensive analysis of 21 prospective cohorts.Cancer medicine · 2020Pooled it
- Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort Studies.Oncoimmunology · 2020Pooled it
- Population-level cancer trends among solid organ transplant recipients in the United States during 1995-2021.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Practical Guide to Address Common Myths in the Pre- and Post-kidney Transplant Management of the Elderly Patient with Cancer: An Opinion Paper.Transplantation direct · 2026Article
- Assessment of colorectal cancer recurrence risk following solid organ transplantation.Journal of gastrointestinal oncology · 2026Article
- Liver Transplantation Is Associated With a Reduced Risk of Colorectal Dysplasia in Patients With IBD and Concomitant PSC.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Should We Screen Sooner? Elevated CRC Incidence in Solid Organ Transplant Recipients in the United States Before and After the COVID-19 Pandemic.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Epidemiological Overview of Colorectal Cancer in Kidney Transplant Recipients: A Systematic Review.Cancers · 2025Review
- Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization.Discover oncology · 2025Article
- Frontiers and Controversies in De Novo Gastrointestinal Tumors After Organ Transplantation: Current Progress and Future Directions.Annals of surgical oncology · 2025Review
- Gut mucosa alterations after kidney transplantation: a cross sectional study.Journal of nephrology · 2025Article
- Safety of Colonoscopies in Patients on Advanced Heart Failure Therapies Who Received a Heart Transplant.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Colorectal cancer in ulcerative colitis after liver transplantation for primary sclerosing cholangitis: a systematic review and pooled analysis of oncological outcomes.Discover oncology · 2024Review
- Sex differences in cancer incidence among solid organ transplant recipients.Journal of the National Cancer Institute · 2024Article
- Article
- Previous Solid Organ Transplantation Influences Both Cancer Treatment and Survival Among Colorectal Cancer Patients.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Cancer Risk Following HLA-Incompatible Living Donor Kidney Transplantation.Transplantation direct · 2023Article
- Guilty by association? The complex relationship between immunosuppressants and cancer.BMJ oncology · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Solid organ transplant recipients have increased colorectal cancer (CRC) risk. We assessed CRC risk among transplant recipients and identified factors contributing to this association. The US transplant registry was linked to 15 population-based cancer registries (1987-2010). We compared CRC risk in recipients to the general population by using standardized incidence ratios (SIRs) and identified CRC risk factors by using Poisson regression. Based on 790 cases of CRC among 224 098 transplant recipients, the recipients had elevated CRC risk (SIR 1.12, 95% confidence interval [CI] 1.04 to 1.20). The increase was driven by an excess of proximal colon cancer (SIR 1.69, 95% CI 1.53 to 1.87), while distal colon cancer was not increased (SIR 0.93, 95% CI 0.80 to 1.07), and rectal cancer was reduced (SIR 0.64, 95% CI 0.54 to 0.76). In multivariate analyses, CRC was increased markedly in lung recipients with cystic fibrosis (incidence rate ratio [IRR] 12.3, 95% CI 6.94 to 21.9, vs. kidney recipients). Liver recipients with primary sclerosing cholangitis and inflammatory bowel disease also had elevated CRC risk (IRR 5.32, 95% CI 3.73 to 7.58). Maintenance therapy with cyclosporine and azathioprine was associated with proximal colon cancer (IRR 1.53, 95% CI 1.05 to 2.23). Incidence was not elevated in a subgroup of kidney recipients treated with tacrolimus and mycophenolate mofetil, pointing to the relevance of the identified risk factors. Transplant recipients have increased proximal colon cancer risk, likely related to underlying medical conditions (cystic fibrosis and primary sclerosing cholangitis) and specific immunosuppressive regimens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.