ArticleTranslational psychiatry2016
Connectomic markers of disease expression, genetic risk and resilience in bipolar disorder.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Facial emotion recognition deficits in bipolar disorder: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies.The lancet. Psychiatry · 2023Pooled it
- Networks underpinning emotion: A systematic review and synthesis of functional and effective connectivity.NeuroImage · 2021Pooled it
- Inter-network Effective Connectivity During an Emotional Working Memory Task in Two Independent Samples of Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Working memory network dysfunction in bipolar I vs. bipolar II disorder: a systematic review of task-fMRI evidence.Frontiers in psychiatry · 2026Review
- 'Will They Have It Too?' Mothers' Perspectives of Familial Risk for Eating Disorders.Child psychiatry and human development · 2025Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Brain signatures of catastrophic events: Emotion, salience, and cognitive control.Psychophysiology · 2024Article
- Evidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway.Schizophrenia bulletin · 2022Article
- Increased functional interaction within frontoparietal network during working memory task in major depressive disorder.Human brain mapping · 2021Article
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Dynamic Causal Modeling Self-Connectivity Findings in the Functional Magnetic Resonance Imaging Neuropsychiatric Literature.Frontiers in neuroscience · 2021Review
- Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks.Molecular psychiatry · 2019Review
- A cross-disorder connectome landscape of brain dysconnectivity.Nature reviews. Neuroscience · 2019Review
- Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder.Current psychiatry reports · 2019Review
- Telomere length as a predictor of emotional processing in the brain.Human brain mapping · 2019Article
- The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder.PloS one · 2019Article
- An integrated brain-behavior model for working memory.Molecular psychiatry · 2018Article
- Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.Molecular psychiatry · 2018Article
- Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Bipolar disorder (BD) is characterized by emotional dysregulation and cognitive deficits associated with abnormal connectivity between subcortical-primarily emotional processing regions-and prefrontal regulatory areas. Given the significant contribution of genetic factors to BD, studies in unaffected first-degree relatives can identify neural mechanisms of genetic risk but also resilience, thus paving the way for preventive interventions. Dynamic causal modeling (DCM) and random-effects Bayesian model selection were used to define and assess connectomic phenotypes linked to facial affect processing and working memory in a demographically matched sample of first-degree relatives carefully selected for resilience (n=25), euthymic patients with BD (n=41) and unrelated healthy controls (n=46). During facial affect processing, patients and relatives showed similarly increased frontolimbic connectivity; resilient relatives, however, evidenced additional adaptive hyperconnectivity within the ventral visual stream. During working memory processing, patients displayed widespread hypoconnectivity within the corresponding network. In contrast, working memory network connectivity in resilient relatives was comparable to that of controls. Our results indicate that frontolimbic dysfunction during affect processing could represent a marker of genetic risk to BD, and diffuse hypoconnectivity within the working memory network a marker of disease expression. The association of hyperconnectivity within the affect-processing network with resilience to BD suggests adaptive plasticity that allows for compensatory changes and encourages further investigation of this phenotype in genetic and early intervention studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.