ArticlePloS one2016
Substance P and Acute Pain in Patients Undergoing Orthopedic Surgery.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Efficacy and safety of baclofen in the prophylaxis of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a randomized controlled trial.BMC surgery · 2026Trial
- Effect of Transauricular Vagus Nerve Stimulation on Rebound Pain After Ropivacaine Single Injection Femoral Nerve Block for Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial.Journal of pain research · 2022Trial
- Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Trial
- The effects of three kinds of non-steroidal anti-inflammatory drugs on postoperative pain and on the serum levels of tumour necrosis factor-α and substance P in paediatric patients following orthopaedic hip surgery.Archives of medical science : AMS · 2026Article
- The Role of Biomarkers in Acute Pain: A Narrative Review.Pain and therapy · 2025Review
- Effect of classical music on light-plane anaesthesia and analgesia in dogs subjected to surgical nociceptive stimuli.Scientific reports · 2024Article
- Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
- Elevated Substance P Is a Risk Factor for Postoperative Delirium in Patients with Hip Fracture.BioMed research international · 2022Article
- Review
- The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond.International journal of molecular sciences · 2021Review
- Article
- Substance P as a potential biomarker of pain assessment in dogs.Iranian journal of veterinary research · 2019Article
- Gene expression changes in the cerebellum are associated with persistent post-injury pain in adolescent rats exposed to early life stress.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is a limited information about the role of Substance P (SP) in acute pain nociception following surgical stimulation in patients with a chronic inflammatory state not to mention the link between this neuropeptide level changes and intensity of pain. The goal of the research was to find the correlation between SP level changes and acute pain intensity in patients with rheumatoid arthritis undergoing elective orthopedic surgery. MATERIAL AND
methodsPatients with rheumatoid arthritis (RA) were enrolled in the study. The correlation between acute pain intensity and concentration of SP in serum as well as in drainage fluid from postoperative wound was assessed in patients with RA who underwent Total Knee Replacement (TKA) under spinal anesthesia.
resultsIn patients with RA a correlation between intensity of acute pain and serum SP was found postoperatively, whereas there was no correlation between intensity of acute pain and concentration of SP in drainage fluid.
conclusions1. The correlation between acute pain intensity and SP serum concentration was found postoperatively in patients with RA. 2. The correlation between acute pain intensity and SP concentration in drainage fluid was not found postoperatively in patients with RA.
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Registered trials
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