Evidence map›Paper›PMID 26731299›Full record

ArticleSubstance abuse

Characteristics of methadone maintenance treatment patients prescribed opioid analgesics.

Matthew C Glenn, Nancy L Sohler, Joanna L Starrels, Jeronimo Maradiaga, John J Jost, Julia H Arnsten, Chinazo O Cunningham

Open access · greenAbstract read
In one paragraph

Article in Substance abuse. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Matthew C Glenna Albert Einstein College of Medicine , Bronx , New York , USA.
Nancy L Sohlerb The City College of New York, Sophie Davis School of Biomedical Education , New York , New York , USA.
Joanna L Starrelsa Albert Einstein College of Medicine , Bronx , New York , USA.
Jeronimo Maradiagaa Albert Einstein College of Medicine , Bronx , New York , USA.
John J Josta Albert Einstein College of Medicine , Bronx , New York , USA.
Julia H Arnstena Albert Einstein College of Medicine , Bronx , New York , USA.
Chinazo O Cunninghama Albert Einstein College of Medicine , Bronx , New York , USA.
Albert Einstein College of Medicine · USCity College of New York · USMontefiore Medical Center · US

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI KIM, MIMI Y · 2003 to 2013
$18.6M
Abstinence Reinforcing Contingency Management to Suppress HIV Viral LoadR01DA032110 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUNNINGHAM, CHINAZO · 2011 to 2015
$3.6M
HIV and Substance Abuse Clinical Addiction Research and Education (CARE) ProgramR25DA023021 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ARNSTEN, JULIA H. · 2007 to 2014
$2.7M
Prescription opioid use, misuse, disorders and HIV outcomesR01DA039046 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STARRELS, JOANNA L. · 2015 to 2018
$2.4M
Mentoring researchers on drug abuse and HIVK24DA036955 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUNNINGHAM, CHINAZO · 2014 to 2019
$911k
Intervention to Promote Opioid Treatment Agreements in Primary CareK23DA027719 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STARRELS, JOANNA L. · 2010 to 2014
$909k
Resilience in HIV infected drug usersR03DA039727 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUNNINGHAM, CHINAZO · 2016 to 2017
$167k
NIAID NIH HHS P30 AI051519NIDA NIH HHS K23 DA027719NIDA NIH HHS K24 DA036955NIDA NIH HHS R01 DA032110NIDA NIH HHS R01 DA039046NIDA NIH HHS R03 DA039727NIDA NIH HHS R25 DA023021
6 · The paper itself

Abstract

backgroundOpioid analgesic use and disorders have dramatically increased among the general American population and those receiving methadone maintenance treatment (MMT). Most research among MMT patients focuses on opioid analgesics misuse or disorders; few studies focus on MMT patients prescribed opioid analgesics. We describe demographic, clinical, and substance use characteristics of MMT patients prescribed opioid analgesics and compare them with MMT patients not prescribed opioid analgesics.

methodsWe conducted a cross-sectional secondary data analysis using screening interviews from a parent study. From 2012 to 2015, we recruited adults from 3 MMT Bronx clinics. Questionnaire data included patterns of opioid analgesic use, substance use, comorbid illnesses, and demographic characteristics. Our main dependent variable was patients' report of currently taking prescribed opioid analgesics. To compare characteristics between MMT patients prescribed and not prescribed opioid analgesics, we conducted chi-square tests, t tests, and Mann-Whitney U tests.

resultsOf 611 MMT patients, most reported chronic pain (62.0%), hepatitis C virus (HCV) infection (52.1%), and current use of illicit substances (64.2%). Of the 29.8% who reported currently taking prescribed opioid analgesics, most misused their opioid analgesics (57.5%). Patients prescribed (versus not prescribed) opioid analgesics were more likely to report human immunodeficiency virus (HIV) infection (adjusted odds ratio [aOR] = 1.6, 95% confidence interval [CI]: 1.1-2.3) and chronic pain (aOR = 7.6, 95% CI: 4.6-12.6).

conclusionAmong MMT patients primarily in 3 Bronx clinics, nearly one third reported taking prescribed opioid analgesics. Compared with patients not prescribed opioid analgesics, those prescribed opioid analgesics were more likely to report chronic pain and HIV infection. However, between these patients, there was no difference in illicit substance use. These findings highlight the complexity of addressing chronic pain in MMT patients.

Indexed as

Opiate Substitution TreatmentAnalgesics, OpioidChronic PainComorbidityCross-Sectional StudiesDrug UsersFemaleHepatitis CHIV InfectionsHumansMaleMethadoneMiddle AgedNew York CityRandomized Controlled Trials as TopicAnalgesics, OpioidMethadoneHIVmethadoneopiate substitution therapyopioid analgesicspainsubstance use

Identifiers

PMID26731299
PMCPMC4935628
OpenAlexW2297821464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.