ArticleColloids and surfaces. B, Biointerfaces2016
Controlling fungal biofilms with functional drug delivery denture biomaterials.
Article in Colloids and surfaces. B, Biointerfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Pterostilbene-Incorporated Tissue Conditioners Exhibit Sustained Antifungal Activity AgainstMaterials (Basel, Switzerland) · 2026Article
- Impact of graphene oxide nanosheets and polymethyl methacrylate on nano/hybrid-based restoration dental filler composites: ultrasound behavior and antibacterial activity.Journal of ultrasound · 2025Article
- Long-term antifungal drug-delivery denture materials with plasma-initiated surface functionalization.Colloids and surfaces. B, Biointerfaces · 2025Article
- Nanotechnology meets medicine: applications of atomic force microscopy in disease.Biophysical reviews · 2025Review
- Cross-Linked Poly(methyl methacrylate) Nanocomposites' Synthesis, Characterization, and Antibacterial Effects.Polymers · 2025Article
- Antifungal Effect of Poly(methyl methacrylate) with Farnesol and Undecylenic Acid againstMaterials (Basel, Switzerland) · 2024Article
- Mapping the research landscape of nanoparticles and their use in denture base resins: a bibliometric analysis.Discover nano · 2024Article
- Mechanical Characterization of Dental Prostheses Manufactured with PMMA-Graphene Composites.Materials (Basel, Switzerland) · 2022Article
- Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.International journal of molecular sciences · 2022Review
- Poly(methyl methacrylate) with Oleic Acid as an EfficientMaterials (Basel, Switzerland) · 2022Article
- Bio-Interactive Zwitterionic Dental Biomaterials for Improving Biofilm Resistance: Characteristics and Applications.International journal of molecular sciences · 2020Review
- Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment.Molecules (Basel, Switzerland) · 2020Review
- Novel Dental Poly (Methyl Methacrylate) Containing Phytoncide for Antifungal Effect and Inhibition of Oral Multispecies Biofilm.Materials (Basel, Switzerland) · 2020Article
- Advances in Biomaterials for the Prevention and Disruption ofFrontiers in microbiology · 2020Review
- Carbon nanotube incorporation in PMMA to prevent microbial adhesion.Scientific reports · 2019Article
- Salivary polypeptide/hyaluronic acid multilayer coatings act as "fungal repellents" and prevent biofilm formation on biomaterials.Journal of materials chemistry. B · 2018Article
- Effects on cytotoxicity and antibacterial properties of the incorporations of silver nanoparticles into the surface coating of dental alloys.Journal of Zhejiang University. Science. B · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Candida-associated denture stomatitis (CADS), caused by colonization and biofilm-formation of Candida species on denture surfaces, is a significant clinical concern. We show here that modification of conventional denture materials with functional groups can significantly increase drug binding capacity and control drug release rate of the resulting denture materials for potentially managing CADS. In our approach, poly(methyl methacrylate) (PMMA)-based denture resins were surface grafted with three kinds of polymers, poly(1-vinyl-2-pyrrolidinone) (PNVP), poly(methacrylic acid) (PMAA), and poly(2-hydroxyethyl methacrylate) (PHEMA), through plasma-initiated grafting polymerization. With a grafting yield as low as 2 wt%, the three classes of new functionalized denture materials showed significantly higher drug binding capacities toward miconazole, a widely used antifungal drug, than the original PMMA denture resin control, leading to sustained drug release and potent biofilm-controlling effects against Candida. Among the three classes of functionalized denture materials, PNVP-grafted resin provided the highest miconazole binding capability and the most powerful antifungal and biofilm-controlling activities. Drug binding mechanisms were studied. These results demonstrated the importance of specific interactions between drug molecules and functional groups on biomaterials, shedding lights on future design of CADS-managing denture materials and other related devices for controlled drug delivery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.