ArticlePloS one2016
Construction of Radial Defect Models in Rabbits to Determine the Critical Size Defects.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Induced membrane-mediated DBM in combination with PRP: an autologous bone graft substitute therapy with remarkable osteoformation potency for challenging bone defects.International journal of surgery (London, England) · 2026Article
- Novel Techniques and Future Perspective for Investigating Critical-Size Bone Defects.Bioengineering (Basel, Switzerland) · 2022Review
- Does zinc oxide nanoparticles potentiate the regenerative effect of platelet-rich fibrin in healing of critical bone defect in rabbits?BMC veterinary research · 2022Article
- An overview of de novo bone generation in animal models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Effect of low-level laser therapy on the membrane induced by the Masquelet technique at an orthotopic site in rabbits.Acta cirurgica brasileira · 2021Article
- The Impact of Bioceramic Scaffolds on Bone Regeneration in PreclinicalMaterials (Basel, Switzerland) · 2020Review
- Guided Bone Regeneration with Ammoniomethacrylate-Based Barrier Membranes in a Radial Defect Model.BioMed research international · 2020Article
- Form and functional repair of long bone using 3D-printed bioactive scaffolds.Journal of tissue engineering and regenerative medicine · 2018Article
- Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Determining the critical size of a rabbit rib segmental bone defect model.Regenerative biomaterials · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies aimed at investigating bone repair have been conducted through animal models in recent years. However, limitations do exist in these models due to varying regeneration potential among different animal species. Even using the same animal, big differences exist in the size of critical size defects (CSD) involving the same region. This study aimed to investigate the standardization of radial bone defect models in rabbits and further establish more reliable CSD data. A total of 40 6-month-old New Zealand white rabbits of clean grade totaling 80 radial bones were prepared for bone defect models, according to the principle of randomization. Five different sizes (1.0, 1.2, 1.4, 1.7 and 2.0 cm) of complete periosteal defects were introduced under anesthesia. At 12 weeks postoperatively, with the gradual increase in defect size, the grades of bone growth were significantly decreased in all 5 groups. X-ray, CT scans and H&E staining of the 1.4, 1.7, and 2.0-cm groups showed lower grades of bone growth than that of the 1.0 and 1.2-cm groups respectively (P < 0.05). Using rabbit radial defect model involving 6-month-old healthy New Zealand white rabbits, this study indicates that in order to be critical sized, defects must be greater than 1.4 cm.
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