Evidence map›Paper›PMID 26730726›Full record

ArticleAquatic toxicology (Amsterdam, Netherlands)2016

Hexavalent chromium is cytotoxic and genotoxic to American alligator cells.

Sandra S Wise, Catherine Wise, Hong Xie, Louis J Guillette, Cairong Zhu, John Pierce Wise, John Pierce Wise

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aquatic toxicology (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. It's a gator tale: Alligator lung cells resist hexavalent chromium-induced DNA repair inhibition and chromosome instability.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Sandra S WiseWise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103, USA.
Catherine WiseWise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103, USA; Program in Environmental and Molecular Toxicology, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Hong XieWise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103, USA.
Louis J GuilletteMarine Biomedicine and Environmental Sciences Center, Medical University of South Carolina, USA.
Cairong ZhuDepartment of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu 610044, China.
John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103, USA; Department of Health Sciences, Purdue University, West Lafayette, IN 47907, USA.
John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103, USA. Electronic address: john.wise@louisville.edu.
University of Southern Maine · USMedical University of South Carolina · USNorth Carolina State University · USPurdue University West Lafayette · USSichuan University · CN

Funding

PARTICULATE CR(VI) TOXICOLOGY IN HUMAN LUNG EPITHELIAL CELLS AND FIBROBLASTS (Admin Supplement/PA-17-055)R01ES016893 · NIEHS · UNIVERSITY OF SOUTHERN MAINE · PI WISE, JOHN PIERCE · 2009 to 2021
$5.1M
NIEHS NIH HHS R01 ES016893NIEHS NIH HHS R01ES016893
6 · The paper itself

Abstract

Metals are a common pollutant in the aquatic ecosystem. With global climate change, these levels are anticipated to rise as lower pH levels allow sediment bound metals to be released. The American alligator (Alligator mississippiensis) is an apex predator in the aquatic ecosystem and is considered a keystone species; as such it serves as a suitable monitor for localized pollution. One metal of increasing concern is hexavalent chromium (Cr(VI)). It is present in the aquatic environment and is a known human carcinogen and reproductive toxicant. We measured the cytotoxicity and genotoxicity of Cr(VI) in American alligator cells derived from scute tissue. We found that particulate and soluble Cr(VI) are both cytotoxic and genotoxic to alligator cells in a concentration-dependent manner. These data suggest that alligators may be used as a model for assessing the effects of environmental Cr(VI) contamination as well as for other metals of concern.

Indexed as

Alligators and CrocodilesAnimalsCell LineCells, CulturedCell SurvivalChromiumChromosome AberrationsClimate ChangeDNA DamageSkinUnited StatesWater Pollutants, ChemicalChromiumchromium hexavalent ionWater Pollutants, ChemicalAmerican alligatorAquatic modelChromiumCytotoxicityGenotoxicityHexavalent chromium

Identifiers

PMID26730726
PMCPMC4721530
OpenAlexW2191145139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.