Evidence map›Paper›PMID 26730578›Full record

ReviewBritish journal of cancer2016

Epidemiologic studies of the human microbiome and cancer.

Emily Vogtmann, James J Goedert

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 118 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 2 pooled it
24.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03068546 completednot on this mapstarted 2017, after this paper: background citation

Long Term Stability of Oral Microbiome Samples

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2017 to 2019Enrolled30ConditionsOral Microbiota, Long Term Sample Stability
NCT04079400 completednot on this map

Microbiome in Patients With Pulmonary Tuberculosis, Non-tuberculous Mycobacterial Pulmonary Diseases (NTM-PD), Lung Cancer and Hemoptysis

Typeobservational_patient_registrySponsorGachon University Gil Medical CenterRan2016 to 2019Enrolled43ConditionsTuberculosis, Pulmonary, Non-Tuberculous Mycobacterial Pneumonia, Lung Cancer, Hemoptysis
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 2 syntheses or guidelines pooled it, 204 citations in OpenAlex.

  1. The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Pooled it
  2. Pooled it
  3. Gut Microbiome Composition Predicts Infection Risk During Chemotherapy in Children With Acute Lymphoblastic Leukemia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. The Urinary Microbiota and the Gut-Bladder Axis in Bladder Cancer.International journal of molecular sciences · 2025
    Review
  13. Review
  14. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Review
  16. Inflammation, microbiota, and pancreatic cancer.Cancer cell international · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Emily VogtmannNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
James J GoedertInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
National Cancer Institute · USNational Institutes of Health · US

Funding

Microbes and Human MalignanciesZIACP010214 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI VOGTMANN, EMILY · 2010 to 2021
$5.5M
Intramural NIH HHS ZIA CP010214NCI NIH HHS ZIA-CP-010214
6 · The paper itself

Abstract

The human microbiome, which includes the collective genome of all bacteria, archaea, fungi, protists, and viruses found in and on the human body, is altered in many diseases and may substantially affect cancer risk. Previously detected associations of individual bacteria (e.g., Helicobacter pylori), periodontal disease, and inflammation with specific cancers have motivated studies considering the association between the human microbiome and cancer risk. This short review summarises microbiome research, focusing on published epidemiological associations with gastric, oesophageal, hepatobiliary, pancreatic, lung, colorectal, and other cancers. Large, prospective studies of the microbiome that employ multidisciplinary laboratory and analysis methods, as well as rigorous validation of case status, are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, screening, and treatment.

Indexed as

Bacterial InfectionsCarrier StateEpidemiologic StudiesHigh-Throughput Nucleotide SequencingHumansMicrobiotaNeoplasmsRisk Factors

Identifiers

PMID26730578
PMCPMC4742587
OpenAlexW2228700263

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.