ArticleeNeuro
Loss of Projections, Functional Compensation, and Residual Deficits in the Mammalian Vestibulospinal System of Hoxb1-Deficient Mice.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
- Modulation of striatal cAMP levels: A key pathway in the treatment of hyperkinetic movement disorders.iScience · 2026Article
- No need to rethink sensorimotor circuits-Commentary on Goldblatt et al. (2024).Frontiers in neurology · 2025Article
- The Vestibulospinal Nucleus Is a Locus of Balance Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The vestibulospinal nucleus is a locus of balance development.bioRxiv : the preprint server for biology · 2024Article
- Hodological patterning as an organizing principle in vertebrate motor circuitry.Frontiers in neuroanatomy · 2024Review
- Organization of vestibular circuits for postural control in zebrafish.Current opinion in neurobiology · 2023Review
- Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.PLoS genetics · 2023Article
- Article
- Integrated software for multi-dimensional analysis of motion using tracking, electrophysiology, and sensor signals.Frontiers in bioengineering and biotechnology · 2023Article
- The Vestibular Column in the Mouse: A Rhombomeric Perspective.Frontiers in neuroanatomy · 2021Review
- Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain.Frontiers in neuroanatomy · 2021Review
- Temporal Vestibular Deficits inFrontiers in molecular neuroscience · 2020Article
- Diversity of reticulospinal systems in mammals.Current opinion in physiology · 2019Article
- Article
- Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain.Brain structure & function · 2017Article
- Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective.Brain, behavior and evolution · 2017Review
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
- Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development.Frontiers in neural circuits · 2017Review
- Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The genetic mechanisms underlying the developmental and functional specification of brainstem projection neurons are poorly understood. Here, we use transgenic mouse tools to investigate the role of the gene Hoxb1 in the developmental patterning of vestibular projection neurons, with particular focus on the lateral vestibulospinal tract (LVST). The LVST is the principal pathway that conveys vestibular information to limb-related spinal motor circuits and arose early during vertebrate evolution. We show that the segmental hindbrain expression domain uniquely defined by the rhombomere 4 (r4) Hoxb1 enhancer is the origin of essentially all LVST neurons, but also gives rise to subpopulations of contralateral medial vestibulospinal tract (cMVST) neurons, vestibulo-ocular neurons, and reticulospinal (RS) neurons. In newborn mice homozygous for a Hoxb1-null mutation, the r4-derived LVST and cMVST subpopulations fail to form and the r4-derived RS neurons are depleted. Several general motor skills appear unimpaired, but hindlimb vestibulospinal reflexes, which are mediated by the LVST, are greatly reduced. This functional deficit recovers, however, during the second postnatal week, indicating a substantial compensation for the missing LVST. Despite the compensatory plasticity in balance, adult Hoxb1-null mice exhibit other behavioral deficits that manifest particularly in proprioception and interlimb coordination during locomotor tasks. Our results provide a comprehensive account of the developmental role of Hoxb1 in patterning the vestibular system and evidence for a remarkable developmental plasticity in the descending control of reflex limb movements. They also suggest an involvement of the lateral vestibulospinal tract in proprioception and in ensuring limb alternation generated by locomotor circuitry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.