Evidence map›Paper›PMID 26730341›Full record

ArticleIranian journal of basic medical sciences2015

The effects of dried root aqueous extract of Salvia miltiorrhiza and its major ingredient in acceleration of orthodontic tooth movement in rat.

Li-Qun Xiao, Hong-Tao Wang, Yu-Lan Li, Qing Zeng, E Zhou, Xia Ni, Zhong-Ping Huan

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. [Adjunctive interventions to accelerate orthodontic tooth movement].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Li-Qun XiaoDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Hong-Tao WangDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Yu-Lan LiDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Qing ZengDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
E ZhouDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Xia NiDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Zhong-Ping HuanDepartment of Stomatology, The First College of Clinical Medical Science of China Three Gorges University, Yichang Central People's Hospital, Yichang 443003, China.
Yichang Central People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSalvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. MATERIALS AND

methodsMale Sprague-Dawley rats (n= 150) were divided into five groups: model control group (0.5 ml/kg phosphate-buffered saline (PBS) injection), ESM group (0.75 g/kg/day of crude drugs) and Danshensu subgroups (250, 500, 750 mg/kg/day of body weight). All rats were administered intramuscularly into the buccal vestibular mucosa of first molar of left maxillary. The indicators such as the moving distance of orthodontic tooth, nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) expression and osteoclasts were tested.

resultsThe expressions of RANKL and OPG in the treatment groups were obviously enhanced compared with control group (P<0.05). The increase rate of OPG expression was slower than that of RANKL. But, RANKL decreased conspicuously after no orthodontic pressure was applied, especially in the treatment groups (Danshengsu high dose group at day 30: 2.17 versus 3.47 of control, P<0.01). ESM groups promoted osteoclasts proliferation in the first 20 days.

conclusionThere is a relationship between RANKL/OPG ratio and the number of osteoclasts. ESM might accelerate periodontal alteration of rat orthodontic tooth via producing more osteoclasts.

Indexed as

DanshensuMovement distancenuclear factor κB ligandOsteoclastsOsteoprotegerinReceptor activator for

Identifiers

PMID26730341
PMCPMC4686576
OpenAlexW1869097127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.