Evidence map›Paper›PMID 26730276›Full record

ReviewWorld journal of hepatology2015

Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases.

Elizabeth Ma Rabelo-Gonçalves, Bruna M Roesler, José Mr Zeitune

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Association betweenWorld journal of hepatology · 2025
    Article
  5. Frontiers in cell and developmental biology · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Impact ofJournal of clinical and translational hepatology · 2023
    Review
  10. The Prevalence of Liver Cytolysis in Children withChildren (Basel, Switzerland) · 2022
    Article
  11. The Microbiome in Gastrointestinal Cancers.Gastroenterology clinics of North America · 2022
    Review
  12. Review
  13. Frontiers in immunology · 2022
    Review
  14. Article
  15. Faecal microbial biomarkers in early diagnosis of colorectal cancer.Journal of cellular and molecular medicine · 2021
    Review
  16. MUC4 is a novel mediator inOncology letters · 2021
    Article
  17. Prevalence ofJournal of tropical medicine · 2021
    Article
  18. World journal of gastroenterology · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Elizabeth Ma Rabelo-GonçalvesElizabeth MA Rabelo-Gonçalves, Bruna M Roesler, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Campinas, São Paulo 13083-878, Brazil.
Bruna M RoeslerElizabeth MA Rabelo-Gonçalves, Bruna M Roesler, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Campinas, São Paulo 13083-878, Brazil.
José Mr ZeituneElizabeth MA Rabelo-Gonçalves, Bruna M Roesler, Laboratory of Gastroenterology and Hepatology, Center of Diagnosis of Digestive Diseases, State University of Campinas, Campinas, São Paulo 13083-878, Brazil.
Creative Research Enterprises (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori (H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases.

Indexed as

CirrhosisDiabetes mellitusFibrosisHelicobacter pyloriHepatic encephalopathyHepatocellular carcinomaMetabolic syndromeNonalcoholic fatty liver diseasePancreatic cancerPancreatitis

Identifiers

PMID26730276
PMCPMC4691700
OpenAlexW2239598736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.