ArticleOncoTargets and therapy2016
Expression of interleukin 1β in gastric cancer tissue and its effects on gastric cancer.
Article in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Evaluation of Inflammatory Biomarkers Gal-1 and IL-1β and Liver Enzyme Activities in Gastric Cancer Patients Pre- and Post-Chemotherapy: A Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The association between poor dental health and gastric cancer risk: a nationwide cohort and sibling-controlled study.BMC medicine · 2025Article
- Impact of IL-6 and IL-1β Gene Variants on Non-small-cell Lung Cancer Risk in Egyptian Patients.Biochemical genetics · 2024Article
- A Meta-Analysis Methodology in Stan to Estimate Population Pharmacokinetic Parameters from Multiple Aggregate Concentration-Time Datasets: Application to Gevokizumab mPBPK Model.Pharmaceutics · 2024Article
- Interleukin-1β: Friend or foe for gastrointestinal cancers.World journal of gastrointestinal oncology · 2024Article
- Triptolide suppresses IL-1β-induced expression of interleukin-8 by inhibiting ROS-Mediated ERK, AP-1, and NF-κB molecules in human gastric cancer AGS cells.Frontiers in oncology · 2024Article
- Paracrine activin B-NF-κB signaling shapes an inflammatory tumor microenvironment in gastric cancer via fibroblast reprogramming.Journal of experimental & clinical cancer research : CR · 2023Article
- Article
- Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging.Frontiers in immunology · 2023Review
- The role of the inflammasome and its related pathways in ovarian cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Review
- Core 1-derived mucin-type O-glycosylation protects against spontaneous gastritis and gastric cancer.The Journal of experimental medicine · 2020Article
- Helicobacter pylori-induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL-1β expression.Cancer medicine · 2019Article
- Resolution of Gastric Cancer-Promoting Inflammation: A Novel Strategy for Anti-cancer Therapy.Current topics in microbiology and immunology · 2019Review
- The contrasting roles of inflammasomes in cancer.American journal of cancer research · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study detected the expression level of IL-1β in gastric cancer tissue and paracarcinoma tissue, and also analyzed its relationship with clinical and pathological features, so as to explore the expression of IL-1β in gastric cancer tissue and its effect on gastric cancer. A total of 70 fresh primary gastric cancer tumors and corresponding paracarcinoma tissues away from the tumor-incision edge (≥5 cm) were selected from the First Affiliated Hospital of Zhengzhou University from January to December 2014. Total protein concentration was extracted from tissues with radioimmunoprecipitation assay lysis buffer, and IL-1β content in tissues was detected with enzyme-linked immunosorbent assay. The ratio of cell cytokine content and protein concentration was considered as the relative content of cytokines, and the relationship between relative content of cytokines and clinical data was analyzed. Results indicated that the differences in content of IL-1β in gastric cancer tissues and paracarcinoma tissues had no statistical significance, but the content of IL-1β would rise as tumor size was enlarged, based upon analysis (2.9<4.2 ng/g), and the difference was statistically significant (P<0.05). Furthermore, IL-1β content decreased along with differentiation degree and infiltration depth (3.21<4.15 ng/g, 3.06<3.45 ng/g), but the difference was not statistically significant (P>0.05). Therefore, it can be concluded that IL-1β plays an important role in the occurrence and development of gastric cancer and promotes the treatment of gastric cancer to some extent.
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