ReviewWorld journal of gastroenterology2015
Hepatolithiasis and intrahepatic cholangiocarcinoma: A review.
Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Systematic review of cholangiocarcinoma in Africa: epidemiology, management, and clinical outcomes.BMC gastroenterology · 2023Pooled it
- A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial.Surgical endoscopy · 2020Trial
- Recurrent Intrahepatic Hepatolithiasis Associated With Low-Phospholipid-Associated Cholelithiasis Syndrome: An Underdiagnosed Pathology.ACG case reports journal · 2026Article
- Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis.Biology direct · 2026Article
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- Article
- Chronic Liver Disease Associated Cholangiocarcinoma: Genomic Insights and Precision Therapeutic Strategies.Cancers · 2025Review
- Imaging and management of complications post biliary-enteric anastomosis.Abdominal radiology (New York) · 2025Review
- Electromagnetic tracking system-assisted ultrasound guidance for percutaneous transhepatic one-step biliary fistulation combined with rigid choledochoscopy in the treatment of hepatolithiasis.Surgical endoscopy · 2025Article
- Western Experience of Hepatolithiasis: Clinical Insights from a Case Series in a Tertiary Center.Medicina (Kaunas, Lithuania) · 2025Article
- Laparoscopic versus open secondary hepatectomy treating postoperative regional recurrent hepatolithiasis: a multicenter real-world study.Surgical endoscopy · 2025Article
- Efficacy and Safety of Percutaneous Transhepatic Lithotripsy Using SpyGlassDSTM Cholangioscopy for the Treatment of Difficult Stones.Diagnostics (Basel, Switzerland) · 2025Article
- Epidemiology and genomic features of biliary tract cancer and its unique features in Korea.Journal of liver cancer · 2025Article
- mm3DSNet: multi-scale and multi-feedforward self-attention 3D segmentation network for CT scans of hepatobiliary ducts.Medical & biological engineering & computing · 2025Article
- Global research trends in surgical management of choledochal cysts: a bibliometric analysis from 2000 to 2024.Frontiers in medicine · 2025Article
- Evolution of surgical treatment for hepatolithiasis.World journal of gastrointestinal surgery · 2024Review
- Hepatolithiasis following hepaticojejunostomy successfully treated with right hepatectomy: A case report.Radiology case reports · 2024Article
- The Epidemiology of Biliary Tract Cancer and Associated Prevalence of MDM2 Amplification: A Targeted Literature Review.Targeted oncology · 2024Review
- Risk factors of cholangiocarcinoma in areas not endemic for liver fluke infection.Asian biomedicine : research, reviews and news · 2024Article
- Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the incidence of hepatolithiasis is decreasing as the pattern of gallstone disease changes in Asia, the prevalence of hepatolithiasis is persistently high, especially in Far Eastern countries. Hepatolithiasis is an established risk factor for cholangiocarcinoma (CCA), and chronic proliferative inflammation may be involved in biliary carcinogenesis and in inducing the upregulation of cell-proliferating factors. With the use of advanced imaging modalities, there has been much improvement in the management of hepatolithiasis and the diagnosis of hepatolithiasis-associated CCA (HL-CCA). However, there are many problems in managing the strictures in hepatolithiasis and differentiating them from infiltrating types of CCA. Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliary-enteric anastomosis. Even after resection, patients should be followed with caution for development of HL-CCA, because HL-CCA is an independent prognostic factor for survival. It is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA. Furthermore, there are no consistent findings regarding prediction of subsequent HL-CCA in patients with hepatolithiasis. In the management of hepatolithiasis, important factors are the reduction of recurrence of cholangitis and suspicion of unrecognized HL-CCA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.