Trial reportProceedings of the National Academy of Sciences of the United States of America2016
Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities.International journal of molecular sciences · 2023Pooled it
- Osteosynthesis devices in absorbable Magnesium alloy in comparison to standard ones: a Systematic Review on effectiveness and safety.Acta bio-medica : Atenei Parmensis · 2021Pooled it
- [Advances in biodegradable medical magnesium alloys for orthopedic applications].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Current status and future prospects of biodegradable magnesium-based implants developed for orthopaedic applications.Journal of orthopaedic translation · 2026Review
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Bandage-Type Autocatalytic PdClACS applied optical materials · 2026Article
- Developing antibacterial Zn-Cu-Mg alloys with high strength and osteogenic stimulation for osteomyelitis.Scientific reports · 2026Article
- Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.Bioactive materials · 2026Article
- Development of bioactive SF/HAp/ZnO scaffolds incorporating succinic acid with potential bone regeneration capabilities.RSC advances · 2026Article
- Physiologically Based Pharmacokinetic Model of Magnesium Implant Absorption and Distribution in Tissue and Organs.ACS omega · 2026Article
- Magnesium degradation-induced variable fixation plates promote the vascularization of femoral fracture in rabbits.Journal of orthopaedic surgery and research · 2026Article
- Study on the effect and mechanism of gold nanocoated magnesium bone scaffolds for bone repair.BMC musculoskeletal disorders · 2025Article
- Strong living scaffolds for load-bearing musculoskeletal tissue regeneration.Materials today. Bio · 2025Review
- Article
- Enhancement of mechanical, corrosion, and biocompatibility properties of zinc alloys through magnesium and neodymium alloying for bone implant applications.RSC advances · 2025Article
- Advancements in biodegradable implants: evaluation in large animal surgical models.Annals of medicine and surgery (2012) · 2025Review
- Osteogenesis Activity and Porosity Effect of Biodegradable Mg-Ga Alloys Barrier Membrane for Guided Bone Regeneration: An in Vitro and in Vivo Study in Rabbits.Biomedicines · 2025Article
- Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals.Bioactive materials · 2025Article
- An In Silico Model to Examine the Interaction Between Implant Degradation and Fracture Healing Under Mechanical Loading.Annals of biomedical engineering · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.