ReviewThe American journal of gastroenterology2016
Diagnosis and Management of Functional Heartburn.
Review in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05901740 (Prevalence of Fuctional Heartburn in Patients With IBS .), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence of Fuctional Heartburn in Patients With IBS .
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Empowering Pharmacists in Heartburn Management: Practical Insights for OTC Treatment and Self-Care.Pharmacy (Basel, Switzerland) · 2025Review
- Clinical diagnostic value of mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index for distinguishing functional heartburn from non-erosive reflux disease.Przeglad gastroenterologiczny · 2025Article
- Non-acid reflux and esophageal dysmotility is associated with early esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease.Journal of neurogastroenterology and motility · 2021Article
- Prevalence and severity of dyspepsia in Saudi Arabia: A survey-based study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Non-acid Reflux: When It Matters and Approach to Management.Current gastroenterology reports · 2020Review
- Reduction in Hospitalizations for Esophageal Reflux in a Decade with Minimal Increases in Other Functional and Motor Disorders.Digestive diseases and sciences · 2020Article
- Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn.Journal of neurogastroenterology and motility · 2019Article
- Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date.Therapeutic advances in gastroenterology · 2018Review
- Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients.BMC gastroenterology · 2017Article
- Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2017Article
- Comparison of Esophageal Function Tests in Chinese Patients with Functional Heartburn and Reflux Hypersensitivity.Gastroenterology research and practice · 2017Article
- Microscopic Esophagitis, Baseline Impedance and Post-Reflux Swallow-Induced Peristaltic Wave in Functional Heartburn: Useful Diagnostic Tools.The American journal of gastroenterology · 2016Article
- About the Diagnosis and Management of Functional Heartburn: Heartburn and Oesophageal Motility Disorders.The American journal of gastroenterology · 2016Article
- Response to Scaringi et al.The American journal of gastroenterology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heartburn is among the most common gastrointestinal symptoms presenting to both generalist physicians and gastroenterologists. Heartburn that does not respond to traditional acid suppression is a diagnostic and therapeutic dilemma. In the era of high utilization of proton pump inhibitors, a substantial proportion of patients presenting to the gastroenterologist with chronic symptoms of heartburn do not have a reflux-mediated disease. Subjects without objective evidence of reflux as a cause of their symptoms have "functional heartburn". The diagnostic role of endoscopy, reflux and motility testing in functional heartburn (FH) patients is discussed. Lifestyle modifications, pharmacological interventions, and alternative therapies for FH are also presented. Recognition of patients with FH allows earlier assignment of these patients to different treatment algorithms, which may allow greater likelihood of success of treatment, diminished resource utilization and improved quality of life. Further data on this large and understudied group of patients is necessary to allow improvement in treatment algorithms and a more evidence-based approach to care of these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.