ArticleAntimicrobial agents and chemotherapy2016
Klebsiella pneumoniae Isolate from a New York City Hospital Belonging to Sequence Type 258 and Carrying blaKPC-2 and blaVIM-4.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- An ICU Outbreak Due to Two Populations of Carbapenem-ResistantMicroorganisms · 2025Article
- An outbreak of blaAntimicrobial resistance and infection control · 2024Article
- Carbapenem Resistance in Gram-Negative Bacteria: A Hospital-Based Study in Egypt.Medicina (Kaunas, Lithuania) · 2023Article
- Drug Resistance Genes and Molecular Epidemiological Characteristics of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Within patient genetic diversity of blaScientific reports · 2021Article
- A Bibliometric Meta-Analysis of Colistin Resistance inDiseases (Basel, Switzerland) · 2021Article
- Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance inmSystems · 2020Review
- Diversity of resistance mechanisms in carbapenem-resistant Enterobacteriaceae at a health care system in Northern California, from 2013 to 2016.Diagnostic microbiology and infectious disease · 2019Article
- CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-ResistantFrontiers in microbiology · 2019Article
- Rapid Identification of Five Classes of Carbapenem Resistance Genes Directly from Rectal Swabs by Use of the Xpert Carba-R Assay.Journal of clinical microbiology · 2017Article
- Low Frequency of Ceftazidime-Avibactam Resistance among Enterobacteriaceae Isolates CarryingAntimicrobial agents and chemotherapy · 2017Article
- The rapid spread of carbapenem-resistant Enterobacteriaceae.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2016Review
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7 authors.
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Abstract
Among 69 of 139 (49.6%) carbapenem-nonsusceptible Enterobacteriaceae carrying blaKPC, 1 Klebsiella pneumoniae was also positive for blaVIM. The isolate belonged to sequence type 258 (ST258) and carried blaKPC-2 on a copy of Tn4401a and blaVIM-4 on a class 1 integron. Genes were located on distinct plasmids belonging to Inc types A/C and FII. Elevated expression of the efflux pump AcrAB-TolC (acrA, 15.3 times) and reduced expression of outer membrane protein genes ompK35 and ompK37 (0.16 and 0.081 times, respectively) associated with various amino acid alterations on OmpK37 were observed. The presence of two carbapenemases in ST258 K. pneumoniae is of great concern due to the ability of this organism to widely disseminate.
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