Evidence map›Paper›PMID 26729503›Full record

ArticleAntimicrobial agents and chemotherapy2016

Complete Sequences of Multidrug Resistance Plasmids Bearing rmtD1 and rmtD2 16S rRNA Methyltransferase Genes.

Maria Fernanda C Bueno, Gabriela R Francisco, Doroti de Oliveira Garcia, Yohei Doi

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Novel Insights intoMicrobiology spectrum · 2022
    Article
  3. Genomic Analysis of Carbapenem-ResistantFrontiers in microbiology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria Fernanda C BuenoCentro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Gabriela R FranciscoCentro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Doroti de Oliveira GarciaCentro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA yod4@pitt.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Markers predicting response to therapy for KPC-producing Klebsiella pneumoniaeR21AI107302 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2013 to 2014
$409k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI104895NIAID NIH HHS R01AI104895NIAID NIH HHS R21 AI107302NIAID NIH HHS R21AI107302
6 · The paper itself

Abstract

Complete nucleotide sequences were determined for two plasmids bearing rmtD group 16S rRNA methyltransferase genes. pKp64/11 was 78 kb in size, belonged to the IncL/M group, and harbored blaTEM-1b, sul1, qacEΔ1, dfrA22, and rmtD1 across two multidrug resistance regions (MRRs). pKp368/10 was 170 kb in size, belonged to the IncA/C group, and harbored acrB, sul1, qacEΔ1, ant(3″)-Ia, aac(6')-Ib, cat, rmtD2, and blaCTX-M-8 across three MRRs. The rmtD-containing regions shared a conserved motif, suggesting a common origin for the two rmtD alleles.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBase Sequencebeta-LactamasesDrug Resistance, Multiple, BacterialEscherichia coliKlebsiella pneumoniaeMembrane Transport ProteinsMethyltransferasesMicrobial Sensitivity TestsPlasmidsRNA, Ribosomal, 16SSequence Analysis, RNAAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-lactamase TEM-1Membrane Transport ProteinsMethyltransferasesRNA, Ribosomal, 16S

Identifiers

PMID26729503
PMCPMC4775959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.