ReviewInternational journal of immunopathology and pharmacology2016
Inflammatory markers and suicidal attempts in depressed patients: A review.
Review in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Secondary Mania induced by TNF-α inhibitors: A systematic review.Psychiatry and clinical neurosciences · 2022Pooled it
- Low 5HTJournal of neurochemistry · 2026Review
- Association between Suicidal Ideation and Immune Parameters in First-episode Patients with Schizophrenia.Current neuropharmacology · 2026Article
- Independent and interactive associations of inflammation, vascular homeostasis markers, and childhood trauma with suicide attempt history.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Article
- Relationship between serum inflammatory cytokines and suicide risk in patients with major depressive disorder.Frontiers in psychiatry · 2024Article
- Interaction effect between childhood abuse and interleukin-1β levels on suicidality in depressed patients.European archives of psychiatry and clinical neuroscience · 2022Article
- Current Perspectives on Pharmacological and Non-Pharmacological Interventions for the Inflammatory Mechanism of Unipolar Depression.Brain sciences · 2022Review
- Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice.Journal of neuroinflammation · 2022Article
- Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats.Genes, brain, and behavior · 2022Article
- Kamikihito rescued depressive-like behaviors and hippocampus neurogenesis in chronic restraint stress rats.Journal of traditional and complementary medicine · 2022Article
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Understanding the Complex of Suicide in Depression: from Research to Clinics.Psychiatry investigation · 2020Article
- Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome.Frontiers in psychiatry · 2020Article
- Novel Treatment Targets Based on Insights in the Etiology of Depression: Role of IL-6 Trans-Signaling and Stress-Induced Elevation of Glutamate and ATP.Pharmaceuticals (Basel, Switzerland) · 2019Review
- In Patients With Multiple Sclerosis, Both Objective and Subjective Sleep, Depression, Fatigue, and Paresthesia Improved After 3 Weeks of Regular Exercise.Frontiers in psychiatry · 2019Article
- Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases.Frontiers in cellular neuroscience · 2019Review
- Scale-Up Synthesis and Identification of GLYX-13, a NMDAR Glycine-Site Partial Agonist for the Treatment of Major Depressive Disorder.Molecules (Basel, Switzerland) · 2018Article
- Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction.World journal of orthopedics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.