ArticleBMJ open2016
Factors associated with presenting late or with advanced HIV disease in the Netherlands, 1996-2014: results from a national observational cohort.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of people who inject drugs among those with HIV late presentation: a meta-analysis.Substance abuse treatment, prevention, and policy · 2022Pooled it
- Implementing HIV teams sustainably improves HIV indicator condition testing rates in hospitals in the Netherlands: the #aware.hiv clinical trial.AIDS (London, England) · 2025Trial
- Promoting HIV-Testing Amongst Gay, Bisexual and Other Men who have Sex with Men in Amsterdam: Systematic Co-creation and Pilot Testing of a Novel Web-Based Intervention.AIDS and behavior · 2026Article
- Differences in HIV testing may determine the first pillar of the HIV care continuum in a cross-border setting.HIV medicine · 2026Article
- Factors influencing the survival of patients with advanced HIV disease in Guinea from 2015 to 2024.BMC public health · 2026Article
- Risk factors for late HIV diagnosis in England, 2015-2023.HIV medicine · 2026Article
- Labor Market Outcomes of People with HIV Pre- and Post-Diagnosis in the Netherlands.Nature communications · 2026Article
- Evaluation of HIV Late Presentation Trends: A Cross-Sectional Analysis from a Leading Ecuadorian Public Hospital.Pathogens (Basel, Switzerland) · 2025Article
- The impact of delay in HIV diagnosis on patient survival: analysis of HIV infection trends from 2007 to 2023.BMC infectious diseases · 2025Article
- Implementing HIV teams to improve HIV indicator condition-guided testing in general practitioner centers in the Netherlands.BMC primary care · 2024Observational
- Sources of Human Immunodeficiency Virus Infections Among Men Who Have Sex With Men With a Migration Background: A Viral Phylogenetic Case Study in Amsterdam, The Netherlands.The Journal of infectious diseases · 2024Article
- The effect of late presentation on HIV related mortality among adolescents in public hospitals of north showa zone Oromiya, Ethiopia; 2022: a retrospective cohort study.BMC infectious diseases · 2024Article
- Late presentations and missed opportunities among newly diagnosed HIV patients presenting to a specialty clinic in Lebanon.Scientific reports · 2024Article
- Stigma as a barrier to integrated substance use and HIV care in Vietnam: A qualitative examination of patient and provider perspectives.Journal of ethnicity in substance abuse · 2024Article
- Barriers and enablers that influence the uptake of HIV testing among heterosexual migrants in the Netherlands.PloS one · 2024Article
- Determinants of HIV late presentation among men who have sex with men in Portugal (2014-2019): who's being left behind?Frontiers in public health · 2024Article
- The roles of the general practitioner and sexual health centre in HIV testing: comparative insights and impact on HIV incidence rates in the Rotterdam area, the Netherlands - a cross-sectional population-based study.BMC public health · 2023Article
- Association of demographics, HCV co-infection, HIV-1 subtypes and genetic clustering with late HIV diagnosis: a retrospective analysis from the Japanese Drug Resistance HIV-1 Surveillance Network.Journal of the International AIDS Society · 2023Article
- Rapid-progressing progressive multifocal leukoencephalopathy in two patients newly diagnosed with HIV: case series and review of literature.Journal of neurovirology · 2023Review
- HIV Late Presenters in Asia: Management and Public Health Challenges.AIDS research and treatment · 2023Review
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8 authors.
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Abstract
objectivesEarly testing for HIV and entry into care are crucial to optimise treatment outcomes of HIV-infected patients and to prevent spread of HIV. We examined risk factors for presentation with late or advanced disease in HIV-infected patients in the Netherlands.
methodsHIV-infected patients registered in care between January 1996 and June 2014 were selected from the ATHENA national observational HIV cohort. Risk factors for late presentation and advanced disease were analysed by multivariable logistic regression. Furthermore, geographical differences and time trends were examined.
resultsOf 20,965 patients, 53% presented with late-stage HIV infection, and 35% had advanced disease. Late presentation decreased from 62% (1996) to 42% (2013), while advanced disease decreased from 46% to 26%. Late presentation only declined significantly among men having sex with men (MSM; p <0.001), but not among heterosexual males (p=0.08) and females (p=0.73). Factors associated with late presentation were: heterosexual male (adjusted OR (aOR), 1.59; 95% CI 1.44 to 1.75 vs MSM), injecting drug use (2.00; CI 1.69 to 2.38), age ≥ 50 years (1.46; CI 1.33 to 1.60 vs 30-49 years), region of origin (South-East Asia 2.14; 1.80 to 2.54, sub-Saharan Africa 2.11; 1.88 to 2.36, Surinam 1.59; 1.37 to 1.84, Caribbean 1.31; 1.13 to 1.53, Latin America 1.23; 1.04 to 1.46 vs the Netherlands), and location of HIV diagnosis (hospital 3.27; 2.94 to 3.63, general practitioner 1.66; 1.50 to 1.83, antenatal screening 1.76; 1.38 to 2.34 vs sexually transmitted infection clinic). No association was found for socioeconomic status or level of urbanisation. Compared with Amsterdam, 2 regions had higher adjusted odds and 2 regions had lower odds of late presentation. Results were highly similar for advanced disease.
conclusionsAlthough the overall rate of late presentation is declining in the Netherlands, targeted programmes to reduce late HIV diagnoses remain needed for all risk groups, but should be prioritised for heterosexual males, migrant populations, people aged ≥ 50 years and certain regions in the Netherlands.
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