Evidence map›Paper›PMID 26729277›Full record

ArticleObesity surgery2016

Differential Acute Impacts of Sleeve Gastrectomy, Roux-en-Y Gastric Bypass Surgery and Matched Caloric Restriction Diet on Insulin Secretion, Insulin Effectiveness and Non-Esterified Fatty Acid Levels Among Patients with Type 2 Diabetes.

Felicity Thomas, Greg C Smith, Jun Lu, Richard Babor, Michael Booth, Grant Beban, J Geoffrey Chase, Rinki Murphy

Registry-linked trialOpen access · greenAbstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03264001 (Effects of Progressive Negative Energy Balance Induced by Diet or Exercise on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03264001 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Effects of Progressive Negative Energy Balance Induced by Diet or Exercise on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function

TypeinterventionalSponsorSingapore Institute of Food and Biotechnology InnovationRan2017 to 2018Enrolled61ConditionsInsulin Sensitivity, Glucose Intolerance, Insulin Resistance, Energy SupplyArmsNegative energy balance
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Felicity ThomasDepartment of Mechanical Engineering, University of Canterbury, Private Bag 8140, Christchurch, New Zealand. felicity.thomas@pg.canterbury.ac.nz.ORCID 0000-0003-1299-2353
Greg C SmithDepartment of Pharmacology, UNSW Australia, Kensington, 2033, Sydney, Australia.
Jun LuSchool of Applied Sciences and School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences and Institute of Biomedical Technology, Auckland University of Technology, Private Bag 92006, Box A-25, Auckland, 1142, New Zealand.
Richard BaborDepartment of General Surgery, Middlemore Hospital, Private Bag 93311, Otahuhu, Auckland, 1640, New Zealand.
Michael BoothDepartment of General Surgery, Waitemata District Hospital Board, Shakespeare Rd, Takapuna, Auckland, New Zealand.
Grant BebanDepartment of General Surgery, Auckland City Hospital, Park Rd, Grafton, Auckland, 1023, New Zealand.
J Geoffrey ChaseDepartment of Mechanical Engineering, University of Canterbury, Private Bag 8140, Christchurch, New Zealand.
Rinki MurphyDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
University of Canterbury · NZAuckland City Hospital · NZAuckland University of Technology · NZMiddlemore Hospital · NZUniversity of Auckland · NZUNSW Sydney · AUWaitemata District Health Board · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery is an increasingly common option for control of type 2 diabetes (T2D) and obesity. Mechanisms underlying rapid improvement of T2D after different types of bariatric surgery are not clear. Caloric deprivation and altered levels of non-esterified fatty acid (NEFA) have been proposed. This study examines how sleeve gastrectomy (SG), Roux-en-Y gastric bypass (GBP) or matched hypocaloric diet (DT) achieves improvements in T2D by characterising components of the glucose metabolism and NEFA levels before and 3 days after each intervention.

methodsPlasma samples at five time points during oral glucose tolerance test (OGTT) from subjects with T2D undergoing GBP (N = 11) or SG (N = 12) were analysed for C-peptide, insulin and glucose before surgery and 3-day post-intervention or after DT (N = 5). Fasting palmitic, linoleic, oleic and stearic acid were measured. C-peptide measurements were used to model insulin secretion rate (ISR) using deconvolution.

resultsSubjects who underwent GBP surgery experienced the greatest improvement in glycaemia (median reduction in blood glucose (BG) from basal by 29 % [IQR -57, -18]) and the greatest reduction in all NEFA measured. SG achieved improvement in glycaemia with lower ISR and reduction in all but palmitoleic acid. DT subjects achieved improvement in glycaemia with an increase in ISR, 105 % [IQR, 20, 220] and stearic acid.

conclusionsGBP, SG and DT each improve glucose metabolism through different effects on pancreatic beta cell function, insulin sensitivity and free fatty acids.

Indexed as

Diet, ReducingGastrectomyGastric BypassAdultBlood GlucoseCaloric RestrictionDiabetes Mellitus, Type 2Fatty AcidsFemaleGlucose Tolerance TestHumansInsulinInsulin ResistanceInsulin-Secreting CellsInsulin SecretionMaleBlood GlucoseFatty AcidsInsulinInsulin secretionNon-esterified fatty acidObesityRoux-en-Y gastric bypassSleeve gastrectomyType 2 diabetesVery low calorie diet

Identifiers

PMID26729277
OpenAlexW2224668954

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.