ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Upregulation of microRNA-31 targeting integrin α5 suppresses tumor cell invasion and metastasis by indirectly regulating PI3K/AKT pathway in human gastric cancer SGC7901 cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.Translational oncology · 2025Article
- ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma.Iranian journal of basic medical sciences · 2023Article
- Construction of a novel ceRNA network and identification of lncRNATranslational cancer research · 2021Article
- MicroRNA-31 Regulates Expression ofInternational journal of molecular sciences · 2020Article
- MicroRNA-26a inhibits wound healing through decreased keratinocytes migration by regulating ITGA5 through PI3K/AKT signaling pathway.Bioscience reports · 2020Article
- [Integrin α5 silencing inhibits proliferation, invasion and metastasis of human liver cancer Bel-7404 cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling.Oncogenesis · 2019Article
- miR-31-5p Is a LIPUS-Mechanosensitive MicroRNA that Targets HIF-1α Signaling and Cytoskeletal Proteins.International journal of molecular sciences · 2019Article
- Tumor necrosis factor-related apoptosis-inducing ligand inhibits the growth and aggressiveness of colon carcinoma via the exogenous apoptosis signaling pathway.Experimental and therapeutic medicine · 2019Article
- Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells.Scientific reports · 2018Article
- Chloroform fraction ofOncology letters · 2018Article
- Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway.International journal of molecular medicine · 2018Article
- Association of differential miRNA expression with hepatic vs. peritoneal metastatic spread in colorectal cancer.BMC cancer · 2018Article
- MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5.Bioscience reports · 2017Article
- p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription.Oncotarget · 2017Article
- Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.Frontiers in immunology · 2017Article
- MicroRNA31-NDRG3 regulation axes are essential for hepatocellular carcinoma survival and drug resistance.Cancer biomarkers : section A of Disease markers · 2017Article
- MicroRNA target for MACC1 and CYR61 to inhibit tumor growth in mice with colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression.Chinese journal of cancer · 2016Article
Corrections and comments
- Retraction · 2021-12-21Manipulation of Images · · see also: https://pubpeer.com/publications/6A2122CB4A9ACDE2C5B2DF8537749C
- Retracted
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To verify the hypothesis that upregulation of microRNA-31 (miR-31) targeting integrin α5 (ITGA5) suppresses tumor cell invasion and metastasis by indirectly regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in human SGC7901 gastric cancer (GC) cells. The miRTarBase was used to predict whether ITGA5 is the target gene of miR-31, which was further confirmed by luciferase reporter gene assay. The SGC7901 GC cells were divided into five groups including the blank, miR-31 mimic, miR-31 mimic control, miR-31 inhibitor, and miR-31 inhibitor control groups. Reverse transcriptase-polymerase chain reaction (RT-PCR), western blotting, cell scratch test, and transwell assays were respectively performed in our study. TGA5 was found as the target gene of miR-31. The RT-PCR detection revealed that, compared with the blank group, ITGA5 messenger RNA (mRNA) expression decreased in the miR-31 mimic group, but increased in the miR-31 inhibitor group. The western blotting examination suggested that the expressions of ITGA5, PI3K, and AKT proteins reduced in the miR-31 mimic group, but enhanced in the miR-31 inhibitor group when compared to the blank group, respectively. The cell scratch and transwell assays indicated that the miR-31 expressions were negatively associated with GC cell migration and invasion. Besides, RT-PCR combined with western blotting demonstrated that the miR-31 expressions were higher in the normal tissues than those in the GC tissues, while the ITGA5 mRNA and protein showed lower expression in the normal tissues than they did in the GC tissues. Our study concluded that upregulation of miR-31 targeting ITGA5 may suppress tumor cell invasion and metastasis by indirectly regulating PI3K/AKT signaling pathway in human SGC7901 GC cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.