SynthesisNutrients2016
Magnesium Levels in Drinking Water and Coronary Heart Disease Mortality Risk: A Meta-Analysis.
Synthesis in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnesium and health outcomes: an umbrella review of systematic reviews and meta-analyses of observational and intervention studies.European journal of nutrition · 2020Pooled it
- The Effect of Magnesium Supplementation on Endothelial Function: A Randomised Cross-Over Pilot Study.International journal of environmental research and public health · 2021Trial
- Comparison of serum calcium, magnesium, phosphate, alkaline phosphatase, and vitamin D levels in children consuming reverse osmosis, non reverse osmosis, and high fluoride drinking water.Scientific reports · 2025Article
- Magnesium depletion scores as a risk factor for prevalence and mortality rates of urinary incontinence: a national survey analysis.Frontiers in nutrition · 2025Article
- The Role of Txnip in Mediating Low-Magnesium-Driven Endothelial Dysfunction.International journal of molecular sciences · 2023Article
- Magnesium Administration in Chronic Kidney Disease.Nutrients · 2023Review
- High manganese and nickel concentrations in human hair and well water and low calcium concentration in blood serum in a pristine area with sulphide-rich bedrock.Environmental geochemistry and health · 2022Article
- Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study.The American journal of clinical nutrition · 2022Article
- The Response of the Human Umbilical Vein Endothelial Cell Transcriptome to Variation in Magnesium Concentration.Nutrients · 2022Article
- The Risk of CVDs from Desalinated Seawater: A Nested Case-Control Study.International journal of environmental research and public health · 2022Article
- Natural Mineral Waters and Metabolic Syndrome: Insights From Obese Male and Female C57BL/6 Mice on Caloric Restriction.Frontiers in nutrition · 2022Article
- Association between magnesium in drinking water and atrial fibrillation incidence: a nationwide population-based cohort study, 2002-2015.Environmental health : a global access science source · 2021Article
- Water Security and Nutrition: Current Knowledge and Research Opportunities.Advances in nutrition (Bethesda, Md.) · 2021Review
- Cross-Talks between the Cardiovascular Disease-Sarcopenia-Osteoporosis Triad and Magnesium in Humans.International journal of molecular sciences · 2021Review
- Differences in health status of Slovak municipalities supplied with drinking water of different hardness values.Environmental geochemistry and health · 2021Article
- Global Variations in the Mineral Content of Bottled Still and Sparkling Water and a Description of the Possible Impact on Nephrological and Urological Diseases.Journal of clinical medicine · 2021Article
- Proposal of New Health Risk Assessment Method for Deficient Essential Elements in Drinking Water-Case Study of the Slovak Republic.International journal of environmental research and public health · 2020Article
- Balneotherapy and hydrotherapy in chronic respiratory disease.Journal of thoracic disease · 2020Review
- Sulphate mineral waters: A medical resource in several disorders.Journal of traditional and complementary medicine · 2020Review
- Associations between hydration state and pregnancy complications, maternal-infant outcomes: protocol of a prospective observational cohort study.BMC pregnancy and childbirth · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies have demonstrated inconsistent associations between drinking water magnesium levels and risk of mortality from coronary heart disease (CHD); thus, a meta-analysis was performed to assess the association between them. Relevant studies were searched by the databases of Cochrane, EMBASE, PubMed and Web of Knowledge. Pooled relative risks (RR) with their 95% CI were calculated to assess this association using a random-effects model. Finally, nine articles with 10 studies involving 77,821 CHD cases were used in this study. Our results revealed an inverse association between drinking water magnesium level and CHD mortality (RR = 0.89, 95% CI = 0.79-0.99, I² = 70.6). Nine of the 10 studies came from Europe, and the association was significant between drinking water magnesium level and the risk of CHD mortality (RR = 0.83, 95% CI = 0.69-0.98). In conclusion, drinking water magnesium level was significantly inversely associated with CHD mortality.
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Registered trials
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