Evidence map›Paper›PMID 26729136›Full record

ArticleMarine drugs2015

Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus.

Li Li, Heng Li, Jianying Qian, Yongfeng He, Jialin Zheng, Zhenming Lu, Zhenghong Xu, Jinsong Shi

Abstract read
In one paragraph

Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Novel Bioactive Peptides fromMarine drugs · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li LiSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. li792051095@163.com.
Heng LiSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. eternal83@163.com.
Jianying QianSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. jackieqian@163.com.
Yongfeng HeSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. 15061888901@163.com.
Jialin ZhengSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. 18262280354@163.com.
Zhenming LuSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. zhenming_lu@163.com.
Zhenghong XuSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. zhenghxu@jiangnan.edu.cn.
Jinsong ShiSchool of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China. shijs@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through characterization and its immunological activity was investigated. MMPX-B2 consisted of d-glucose and d-galctose residues at a molar ratio of 3.51:1.00. The average molecular weight of MMPX-B2 was 510 kDa. This polysaccharide possessed a main chain of (1→4)-linked-α-d-glucopyranosyl residues, partially substituted at the C-6 position by a few terminal β-d-galactose residues or branched chains consisting of (1→3)-linked β-d-galactose residues. Preliminary immunological tests in vitro showed that MMPX-B2 could stimulate the murine macrophages to release various cytokines, and the structure-activity relationship was then established. The present study demonstrated the potential immunological activity of MMPX-B2, and provided references for studying the active ingredients in M. meretrix.

Indexed as

Adjuvants, ImmunologicAnimalsBivalviaMacrophagesMicePolysaccharidesSeawaterStructure-Activity RelationshipAdjuvants, ImmunologicMMPX-B2 polysaccharide, Meretrix meretrixPolysaccharidesimmunological activityMeretrix meretrix Linnaeuspolysaccharidestructure

Identifiers

PMID26729136
PMCPMC4728503

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.