ReviewInternational journal of molecular sciences2016
Cardiovascular Dysfunction Following Burn Injury: What We Have Learned from Rat and Mouse Models.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03085420 (Cardiac Arrhythmias and Dysfunction in the Pediatric Burn Patient), which is not on this map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiac Arrhythmias and Dysfunction in the Pediatric Burn Patient
Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- Evolving Burn Care: The Transition from Life Preservation to Life Restoration-A Narrative Review.Journal of clinical medicine · 2026Review
- Mitochondria as a Therapeutic Target for Burn Injury.Biomolecules · 2026Review
- Review
- Post-burn Lung Inflammation Is Associated With Induction of Pulmonary Cathelicidin-related Antimicrobial Peptide and S100a8 in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Accelerated epigenetic ageing after burn injury.GeroScience · 2025Article
- Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025Review
- Role of oxidative stress in post-burn wound healing.Burns & trauma · 2025Review
- Pathophysiology of Severe Burn Injuries: New Therapeutic Opportunities From a Systems Perspective.Journal of burn care & research : official publication of the American Burn Association · 2024Review
- Screening and Phasewise Management of Burn Injuries.Cureus · 2024Review
- The Role of Ketamine as a Component of Multimodal Analgesia in Burns: A Retrospective Observational Study.Journal of clinical medicine · 2024Article
- [Research advances on post-burn cognitive disorders and its mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Role of medicinal herbs and phytochemicals in post burn management.Inflammopharmacology · 2023Review
- Pediatric First-Degree Burn Management With Honey and 1% Silver Sulfadiazine (Ag-SD): Comparison and Contrast.Cureus · 2022Article
- Review
- Regulation of Key Immune-Related Genes in the Heart Following Burn Injury.Journal of personalized medicine · 2022Article
- Identification of Key Genes in Severe Burns by Using Weighted Gene Coexpression Network Analysis.Computational and mathematical methods in medicine · 2022Article
- Article
- Small animal models of thermal injury.Methods in cell biology · 2022Review
- Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review.International journal of molecular sciences · 2021Review
- Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn-Induced Cardiac Dysfunction.Journal of the American College of Surgeons · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Severe burn profoundly affects organs both proximal and distal to the actual burn site. Cardiovascular dysfunction is a well-documented phenomenon that increases morbidity and mortality following a massive thermal trauma. Beginning immediately post-burn, during the ebb phase, cardiac function is severely depressed. By 48 h post-injury, cardiac function rebounds and the post-burn myocardium becomes tachycardic and hyperinflammatory. While current clinical trials are investigating a variety of drugs targeted at reducing aspects of the post-burn hypermetabolic response such as heart rate and cardiac work, there is still a paucity of knowledge regarding the underlying mechanisms that induce cardiac dysfunction in the severely burned. There are many animal models of burn injury, from rodents, to sheep or swine, but the majority of burn related cardiovascular investigations have occurred in rat and mouse models. This literature review consolidates the data supporting the prevalent role that β-adrenergic receptors play in mediating post-burn cardiac dysfunction and the idea that pharmacological modulation of this receptor family is a viable therapeutic target for resolving burn-induced cardiac deficits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.