Evidence map›Paper›PMID 26729091›Full record

ReviewInternational journal of molecular sciences2015

Targeted Radionuclide Therapy of Human Tumors.

Sergey V Gudkov, Natalya Yu Shilyagina, Vladimir A Vodeneev, Andrei V Zvyagin

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04104529 (Establishment of a Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department), which is not on this map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04104529 narecruitingnot on this mapstarted 2019, after this paper: background citation

Establishment of a Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2019 to 2026Enrolled350ConditionsThyroid Cancer, Prostate Cancer, Neuroendocrine TumorsArmsBiological collection, tumor collection
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 443 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Preclinical Evaluation of 5T4-Targeted [Journal of medicinal chemistry · 2026
    Article
  6. Review
  7. Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  8. DFT calculation of AcScientific reports · 2026
    Article
  9. Evaluation of Daughter Radionuclide Release from thePharmaceuticals (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Advances in Nanobody-Based Platforms for Precision Cancer Diagnosis and Therapy.Polymer science & technology (Washington, D.C.) · 2025
    Review
  14. Enhanced tumor retention and therapeutic potency in radionuclide therapy using GSH-induced self-assembling peptides.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  15. Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Towards the Stable Chelation of Radioantimony(V) for Targeted Auger Theranostics.Angewandte Chemie (International ed. in English) · 2025
    Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Sergey V GudkovLaboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. S_makariy@rambler.ru.
Natalya Yu ShilyaginaLaboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. nat-lekanova@yandex.ru.
Vladimir A VodeneevLaboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. v.vodeneev@mail.ru.
Andrei V ZvyaginLaboratory of Optical Theranostics, Lobachevsky Nizhny Novgorod State University, Gagarin Ave. 23, Nizhny Novgorod 603950, Russia. andrei.zvyagin@mq.edu.au.
Yaroslav-the-Wise Novgorod State University · RUInstitute of Theoretical and Experimental Biophysics · RUMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted radionuclide therapy is one of the most intensively developing directions of nuclear medicine. Unlike conventional external beam therapy, the targeted radionuclide therapy causes less collateral damage to normal tissues and allows targeted drug delivery to a clinically diagnosed neoplastic malformations, as well as metastasized cells and cellular clusters, thus providing systemic therapy of cancer. The methods of targeted radionuclide therapy are based on the use of molecular carriers of radionuclides with high affinity to antigens on the surface of tumor cells. The potential of targeted radionuclide therapy has markedly grown nowadays due to the expanded knowledge base in cancer biology, bioengineering, and radiochemistry. In this review, progress in the radionuclide therapy of hematological malignancies and approaches for treatment of solid tumors is addressed.

Indexed as

RadioimmunotherapyDrug Delivery SystemsHumansNeoplasmsantibodyAuger electronpeptideradio-immunotherapyradionuclidetargeted therapyα-emitterβ-emitter

Identifiers

PMID26729091
PMCPMC4730279
OpenAlexW2211363142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.