ArticleNature communications2016
Local viscoelasticity of living cells measured by rotational magnetic spectroscopy.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 163 citations in OpenAlex.
- Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded Nanoparticles.Chemical & biomedical imaging · 2026Article
- Massart iron oxide nanoparticles in mechanobiology.Nanoscale advances · 2026Review
- Measuring molecular forces inside living cells using magnetic tweezers.Biophysical reviews · 2025Review
- Photothermal Cavitation-Driven Micromotor to Penetrate Cell Membrane.Journal of the American Chemical Society · 2025Article
- SERS-Active Micro/Nanomachines for Biosensing.Biosensors · 2025Review
- The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity.npj biological physics and mechanics · 2025Review
- Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots.Journal of micro-bio robotics · 2025Article
- Density-dependent flow generation in active cytoskeletal fluids.Scientific reports · 2024Article
- Photocatalytic Magnetic Microgyroscopes with Activity-Tunable Precessional Dynamics.Nano letters · 2024Article
- Beyond stiffness: Multiscale viscoelastic features as biomechanical markers for assessing cell types and states.Biophysical journal · 2024Article
- Article
- Single-cell mechanical assay unveils viscoelastic similarities in normal and neoplastic brain cells.Biophysical journal · 2024Article
- Cytoplasmic viscosity is a potential biomarker for metastatic breast cancer cells.Nanoscale advances · 2024Article
- Distinguishing cells using electro-acoustic spinning.Scientific reports · 2023Article
- Viscoelastic Multiscale Mechanical Indexes for Assessing Liver Fibrosis and Treatment Outcomes.Nano letters · 2023Article
- Inductive sensing of magnetic microrobots under actuation by rotating magnetic fields.PNAS nexus · 2023Article
- Article
- Micro-/nanoscale robotics for chemical and biological sensing.Lab on a chip · 2023Review
- Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Manipulation of New Fluorescent Magnetic Nanoparticles with an Electromagnetic Needle, Allowed Determining the Viscosity of the Cytoplasm of M-HeLa Cells.Pharmaceuticals (Basel, Switzerland) · 2023Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When submitted to a magnetic field, micron-size wires with superparamagnetic properties behave as embedded rheometers and represent interesting sensors for microrheology. Here we use rotational magnetic spectroscopy to measure the shear viscosity of the cytoplasm of living cells. We address the question of whether the cytoplasm is a viscoelastic liquid or an elastic gel. The main result of the study is the observation of a rotational instability between a synchronous and an asynchronous regime of rotation, found for murine fibroblasts and human cancer cells. For wires of susceptibility 3.6, the transition occurs in the range 0.01-1 rad s(-1). The determination of the shear viscosity (10-100 Pa s) and elastic modulus (5-20 Pa) confirms the viscoelastic character of the cytoplasm. In contrast to earlier studies, it is concluded that the interior of living cells can be described as a viscoelastic liquid, and not as an elastic gel.
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