Evidence map›Paper›PMID 26728967›Full record

ArticleJournal of biomolecular structure & dynamics2017

Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular dynamics simulations.

Ahmed Alaofi, Elinaz Farokhi, Vivitri D Prasasty, Asokan Anbanandam, Krzysztof Kuczera, Teruna J Siahaan

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  5. Molecular pharmaceutics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Ahmed Alaofia Department of Pharmaceutical Chemistry , The University of Kansas , 2095 Constant Avenue, Lawrence , KS 66047 , USA.
Elinaz Farokhia Department of Pharmaceutical Chemistry , The University of Kansas , 2095 Constant Avenue, Lawrence , KS 66047 , USA.
Vivitri D Prasastya Department of Pharmaceutical Chemistry , The University of Kansas , 2095 Constant Avenue, Lawrence , KS 66047 , USA.
Asokan Anbanandamb Biomolecular NMR Laboratory , The University of Kansas , Shankel Structural Biology Center, 2034 Becker Drive, Lawrence , KS 66045 , USA.
Krzysztof Kuczerac Department of Chemistry and Molecular Biosciences , The University of Kansas , Lawrence , KS 66047 , USA.
Teruna J Siahaana Department of Pharmaceutical Chemistry , The University of Kansas , 2095 Constant Avenue, Lawrence , KS 66047 , USA.
University of Kansas · US

Funding

TRAFFICKING OF THE PLASMA MEMBRANE CA2+-ATPASE TO RAFTSP20RR017708 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI FISCHER, CHRISTOPHER JAMES · 2002 to 2011
$20.1M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
PHARMACEUTICAL ASPECTS OF BIOTECHNOLOGY TRAININGT32GM008359 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J., VOLKIN, DAVID · 1989 to 2018
$5.0M
Modulating the BBB to Improve Drug Delivery to the BrainR01NS075374 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J. · 2011 to 2015
$1.5M
NCRR NIH HHS P20 RR017708NIGMS NIH HHS P30 GM110761NIGMS NIH HHS T32 GM008359NINDS NIH HHS R01 NS075374
6 · The paper itself

Abstract

The goal of this work is to probe the interaction between cyclic cHAVc3 peptide and the EC1 domain of human E-cadherin protein. Cyclic cHAVc3 peptide (cyclo(1,6)Ac-CSHAVC-NH

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein Interaction Domains and MotifsBinding SitesCadherinsHydrogen BondingPeptides, CyclicProtein BindingCadherinsPeptides, Cyclicblood–brain barriercyclic HAV peptideE-cadherin bindingmolecular dynamicsNMR

Identifiers

PMID26728967
PMCPMC5061580
OpenAlexW2239603532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.