ArticlePsychopharmacology2016
Role of prefrontal 5-HT in the strain-dependent variation in sign-tracking behavior of C57BL/6 and DBA/2 mice.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Beyond dopamine: Broader neuromodulatory contributions in sign- and goal-tracking.Psychopharmacology · 2026Review
- Test-retest reliability of the gaze index for sign-tracking and goal-tracking.Behavior research methods · 2026Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- Resting-state brain activation patterns and network topology distinguish human sign and goal trackers.Translational psychiatry · 2024Article
- Leveraging individual differences in cue-reward learning to investigate the psychological and neural basis of shared psychiatric symptomatology: The sign-tracker/goal-tracker model.Behavioral neuroscience · 2024Review
- From skinner box to daily life: Sign-tracker phenotype co-segregates with impulsivity, compulsivity, and addiction tendencies in humans.Cognitive, affective & behavioral neuroscience · 2022Article
- Serotonergic inhibition of responding for conditioned but not primary reinforcers.Pharmacology, biochemistry, and behavior · 2021Article
- Chronic Stress Prevents Cortico-Accumbens Cue Encoding and Alters Conditioned Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies.Frontiers in behavioral neuroscience · 2021Article
- Mapping sign-tracking and goal-tracking onto human behaviors.Neuroscience and biobehavioral reviews · 2020Review
- The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats.eLife · 2019Article
- Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats.Biology of sex differences · 2019Article
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus.PloS one · 2019Article
- Modeling human methamphetamine use patterns in mice: chronic and binge methamphetamine exposure, reward function and neurochemistry.Addiction biology · 2018Article
- Sex-dependent impact of early-life stress and adult immobilization in the attribution of incentive salience in rats.PloS one · 2018Article
- Neurobiological Basis of Individual Variation in Stimulus-Reward Learning.Current opinion in behavioral sciences · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe expression of sign-tracking (ST) phenotype over goal-tracking (GT) phenotype has been associated to different aspects of impulsive behavior, and depletions of brain serotonin (5-HT) have been shown to selectively increase impulsive action as well as ST.
objectivesThe present study aimed at testing the relationship between reduced brain 5-HT availability and expression of ST phenotype in a genetic model of individual variation in brain 5-HT functionality. Inbred DBA/2J (DBA) mice are homozygous for the allelic variant of the TPH-2 gene causing lower brain 5-HT function in comparison with C57BL/6J (C57) inbred mice. MATERIALS: Young adult (10 weeks) and adult (14 weeks) C57 and DBA mice were trained in a Pavlovian conditioned approach (PCA) paradigm. Lever-directed (ST) and magazine-directed (GT) responses were measured in 12 daily conditioning sessions. In a second experiment, effect of the medial prefrontal cortex (mPFC) 5-HT depletion by the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) was assessed on acquisition of ST phenotype in adult C57 mice, according to their higher 5-HT functionality compared to DBA mice.
resultsYoung adult mice of both strains developed ST phenotype, but only adult DBA mice developed ST phenotype. 5-HT depletion in the mPFC of adult C57 mice completely changed their phenotype, as shown by their increased ST.
conclusionsThese findings indicate that ST phenotype can be the expression of a transitory late developmental stage and that genetic factors determine persistence of this phenotype in adulthood. These findings also support a role of 5-HT transmission in PFC in constraining development of ST phenotype.
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