Evidence map›Paper›PMID 26728724›Full record

ArticleDoklady. Biochemistry and biophysics2015

Discordant response of CD4(+) T cells to antiretroviral therapy in HIV-infected patients coinfected with hepatitis C virus is accompanied by increased liver damage.

N G Shmagel, K V Shmagel, E V Saidakova, L B Korolevskaya, V A Chereshnev

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. HCV coinfection of the HIV-infected patients with discordant CD4Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

N G ShmagelPerm State University, Perm, Russia.
K V ShmagelPerm State University, Perm, Russia. shmagel@iegm.ru.
E V SaidakovaPerm State University, Perm, Russia.
L B KorolevskayaPerm State University, Perm, Russia.
V A ChereshnevPerm State University, Perm, Russia.
Institute of Ecology and Genetics of Microorganisms · RUPerm State University · RURegional Center for Prevention and Control of AIDS and Infectious Diseases · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A study of HIV-infected patients coinfected with hepatitis C virus and receiving antiretroviral therapy (ART) but not treated with interferon was performed. Patients were divided into two groups-with standard and inefficient recovery of CD4(+) T cells. It was found that patients with discordant response of CD4(+) T cells to ART showed heavier destructive processes in the liver than the successfully recovered subjects. They had increased levels of ALT and AST. In these patients, the risk of development of liver cirrhosis is greater.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsCD4-Positive T-LymphocytesFemaleHepatitis CHumansLiverMaleTransaminasesAnti-Retroviral AgentsTransaminases

Identifiers

PMID26728724
OpenAlexW2328776425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.