Evidence map›Paper›PMID 26728588›Full record

Observational studyClinical journal of the American Society of Nephrology : CJASN2016

Association of Vascular Access Type with Mortality, Hospitalization, and Transfer to In-Center Hemodialysis in Patients Undergoing Home Hemodialysis.

Matthew B Rivara, Melissa Soohoo, Elani Streja, Miklos Z Molnar, Connie M Rhee, Alfred K Cheung, Ronit Katz, Onyebuchi A Arah, Allen R Nissenson, Jonathan Himmelfarb and 2 more

Open access · bronzeAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Hemodialysis Facilities, Vascular Access Surgeons, and Central Venous Catheter Use: A Retrospective Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Article
  3. Article
  4. From Home to Wearable Hemodialysis: Barriers, Progress, and Opportunities.Clinical journal of the American Society of Nephrology : CJASN · 2024
    Review
  5. Article
  6. Article
  7. Ultrasound guided cannulation of dialysis access.The journal of vascular access · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Vascular Access for Hemodialysis and Value-Based Purchasing for ESRD.Journal of the American Society of Nephrology : JASN · 2017
    Article
  15. Article
  16. The Burden of Harm--What Is the Ideal Vascular Access for Home Hemodialysis?Clinical journal of the American Society of Nephrology : CJASN · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Matthew B RivaraDepartment of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington; mbr@uw.edu.
Melissa SoohooHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Irvine, California;
Elani StrejaHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Irvine, California;
Miklos Z MolnarDivision of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee;
Connie M RheeHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Irvine, California;
Alfred K CheungDivision of Nephrology and Hypertension, University of Utah, Salt Lake City, Utah;
Ronit KatzDepartment of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington;
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California; University of California, Los Angeles (UCLA), Center for Health Policy Research, Los Angeles, California;
Allen R NissensonDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California; and Office of the Chief Medical Officer, DaVita, Inc., El Segundo, California.
Jonathan HimmelfarbDepartment of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington;
Kamyar Kalantar-ZadehHarold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Irvine, California;
Rajnish MehrotraDepartment of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington;
University of California, Irvine Medical Center · USNorthwest Kidney Centers · USOklahoma State University Center for Health Sciences · USUniversity of California, Los Angeles · USUniversity of Tennessee Health Science Center · USUniversity of Utah · USUniversity of Washington · US

Funding

RESEARCH TRAINING IN RENAL DISEASET32DK007467 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA, KESTENBAUM, BRYAN R · 1986 to 2023
$5.1M
Comparative Effectiveness of Dialysis ModalitiesR01DK095668 · NIDDK · UNIVERSITY OF WASHINGTON · PI KALANTAR-ZADEH, KAMYAR, MEHROTRA, RAJNISH · 2012 to 2014
$1.0M
Utility of Early Phase PIB as a Surrogate for Cerebral Blood Flow MeasuresR03AG047306 · NIA · UNIVERSITY OF IOWA · PI PONTO, LAURA LYNN BOLES, SCHULTZ, SUSAN K. · 2014 to 2015
$149k
NIA NIH HHS R03 AG047306NIA NIH HHS R21AG047306NIDDK NIH HHS L30 DK106723NIDDK NIH HHS R01 DK095668NIDDK NIH HHS R01DK095668NIDDK NIH HHS T32 DK007467NIDDK NIH HHS T32DK007467
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn individuals undergoing in-center hemodialysis (HD), use of central venous catheters (CVCs) is associated with worse clinical outcomes compared with use of arteriovenous access. However, it is unclear whether a similar difference in risk by vascular access type is present in patients undergoing home HD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study examined the associations of vascular access type with all-cause mortality, hospitalization, and transfer to in-center HD in patients who initiated home HD from 2007 to 2011 in 464 facilities in 43 states in the United States. Patients were followed through December 31, 2011. Data were analyzed using competing risks hazards regression, with vascular access type at the start of home HD as the primary exposure in a propensity score-matched cohort (1052 patients; 526 with CVC and 526 with arteriovenous access).

resultsOver a median follow-up of 312 days, 110 patients died, 604 had at least one hospitalization, and 202 transferred to in-center hemodialysis. Compared with arteriovenous access use, CVC use was associated with higher risk for mortality (hazard ratio, 1.73; 95% confidence interval, 1.18 to 2.54) and hospitalization (hazard ratio, 1.19; 95% confidence interval, 1.02 to 1.39). CVC use was not associated with increased risk for transfer to in-center HD. The results of analyses in the entire unmatched cohort (2481 patients), with vascular access type modeled as a baseline exposure at start of home HD or a time-varying exposure, were similar. Analyses among a propensity score-matched cohort of patients undergoing in-center HD also showed similar risks for death and hospitalization with use of CVCs.

conclusionsIn a large cohort of patients on home HD, CVC use was associated with higher risk for mortality and hospitalization. Additional studies are needed to identify interventions which may reduce risk associated with use of CVCs among patients undergoing home HD.

Indexed as

HospitalizationAdultAgedArteriovenous Shunt, SurgicalCatheterization, Central VenousFemaleHemodialysis, HomeHumansKidney DiseasesMaleMiddle AgedPropensity ScoreRisk AssessmentRisk FactorsTime FactorsTreatment Outcomearteriovenous fistulaarteriovenous graftcentral venous cathetersend-stage renal diseasefollow-up studieshome hemodialysishospitalizationhumansmortality riskvascular access

Identifiers

PMID26728588
PMCPMC4741041
OpenAlexW2270792432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.