Evidence map›Paper›PMID 26728570›Full record

ArticleMolecular psychiatry2016

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features.

M Heidari, D M Johnstone, B Bassett, R M Graham, A C G Chua, M J House, J F Collingwood, C Bettencourt, H Houlden, M Ryten and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Brain Iron Homeostasis and Mental Disorders.Antioxidants (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Review
  14. Heme: The Lord of the Iron Ring.Antioxidants (Basel, Switzerland) · 2023
    Review
  15. Low-temperature Mössbauer spectroscopy of organs fromJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

M HeidariSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
D M JohnstoneBosch Institute and Discipline of Physiology, University of Sydney, Sydney, NSW, Australia.
B BassettSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
R M GrahamSchool of Biomedical Sciences and Curtin Health Innovation Research Institute - Biosciences, Curtin University of Technology, Bentley, WA, Australia.
A C G ChuaSchool of Medicine and Pharmacology, University of Western Australia, Fiona Stanley Hospital, Murdoch, WA, Australia.
M J HouseSchool of Physics, University of Western Australia, Crawley, WA, Australia.
J F CollingwoodWarwick Engineering in Biomedicine, School of Engineering, University of Warwick, Coventry, UK.ORCID 0000-0001-9090-7690
C BettencourtDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
H HouldenDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
M RytenDepartment of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
J K OlynykSchool of Biomedical Sciences and Curtin Health Innovation Research Institute - Biosciences, Curtin University of Technology, Bentley, WA, Australia.
D TrinderSchool of Medicine and Pharmacology, University of Western Australia, Fiona Stanley Hospital, Murdoch, WA, Australia.
E A MilwardSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
The University of Western Australia · AUUniversity of Newcastle Australia · AUUniversity College London · GBCurtin University · AUKing's College London · GBMurdoch University · AUThe University of Sydney · AUUniversity of Warwick · GB

Funding

Medical Research Council G0802462Medical Research Council G0802760Medical Research Council G1001253Medical Research Council G108/638Medical Research Council MR/J004758/1Wellcome Trust 104033
6 · The paper itself

Abstract

The 'neurodegeneration with brain iron accumulation' (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). Inductively coupled plasma atomic emission spectroscopy demonstrated increased iron in the Hfe

Indexed as

AnimalsBrainGene ExpressionHemochromatosisHemochromatosis ProteinIronIron Metabolism DisordersMembrane ProteinsMiceMice, Inbred AKRMyelin SheathNeuroaxonal DystrophiesPedigreeReceptors, TransferrinHemochromatosis ProteinIronMembrane ProteinsReceptors, TransferrinTFR2 protein, mouse

Identifiers

PMID26728570
PMCPMC5078858
OpenAlexW2226694930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.