Evidence map›Paper›PMID 26728488›Full record

ArticleSchmerz (Berlin, Germany)2016

[Cerebral metabolic changes and chronic back pain: Study taking into consideration clinical and psychological parameters].

L Janetzki, A Gussew, R Malessa, U Habenicht, J R Reichenbach, B Strauß, C Borys

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Schmerz (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

L JanetzkiInstitut für Psychosoziale Medizin und Psychotherapie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Stoystr. 3, 07740, Jena, Deutschland. lisa.janetzki@uni-jena.de.
A GussewMedical Physics Group, Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena, Deutschland.
R MalessaKlinik für Neurologie und Klinische Neurophysiologie, Sophien- und Hufeland-Klinikum, Weimar, Deutschland.
U HabenichtKlinik für Neurologie und Klinische Neurophysiologie, Sophien- und Hufeland-Klinikum, Weimar, Deutschland.
J R ReichenbachMedical Physics Group, Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena, Deutschland.
B StraußInstitut für Psychosoziale Medizin und Psychotherapie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Stoystr. 3, 07740, Jena, Deutschland.
C BorysInstitut für Psychosoziale Medizin und Psychotherapie, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Stoystr. 3, 07740, Jena, Deutschland.
Friedrich Schiller University Jena · DESophien-und Hufeland Klinikum · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe manifestation of chronic pain and psychological impairments are related to alterations of neurotransmitter metabolism in cerebral pain processing regions, e.g., anterior cingular cortex (ACC), insula. Magnetic resonance spectroscopy ((1)H-MRS) enables in vivo quantification of neurotransmitters in the brain and was applied in this study to examine the hypothesized chronic pain-related imbalance between excitatory (glutamatergic) and inhibitory (GABA-ergic) neurotransmitter turnovers in the brain of patients with nonspecific chronic pain. MATERIALS AND

methodsA total of 19 patients with nonspecific chronic (> 3 months) back pain and 19 age- and gender-matched healthy subjects participated in this study. Glutamate and GABA as well as glutamate/GABA ratios were determined in the ACC and insula using (1)H-MRS. Sociodemographic, psychological, and pain-related features were measured with standardized questionnaires.

resultsThere was a strong variance of glutamate/GABA ratios for both patients and healthy subjects with no significant difference between the two groups. Regression analysis revealed certain significant predictors, such as anxiety as causal variable for reduced glutamate and depression and age as predictors for reduced GABA in ACC. In the patient group, intensity of pain was a significant predictor for glutamate and GABA levels in the insula.

conclusionsDespite the uniform diagnosis of nonspecific chronic back pain, we observed a strong variance of neurotransmitters in cerebral pain processing regions. It is necessary to include psychological as well as clinical parameters (e.g., intensity of pain or depression) for a proper interpretation of neurotransmitter turnovers.

Indexed as

Back PainBrainBrain MappingCerebral CortexEnergy MetabolismExcitatory Amino Acidsgamma-Aminobutyric AcidGlutamineGyrus CinguliHumansMagnetic Resonance SpectroscopyNeural InhibitionNeurotransmitter AgentsReference ValuesExcitatory Amino Acidsgamma-Aminobutyric AcidGlutamineNeurotransmitter AgentsChronic painGlutamateProton magnetic resonance spectroscopyPsychological factorsγ-aminobutyric acid

Identifiers

PMID26728488
OpenAlexW2227532929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.