Evidence map›Paper›PMID 26728177›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016

Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.

Torbjörn K Nilsson, Anita Hurtig-Wennlöf, Michael Sjöström, Wolfgang Herrmann, Rima Obeid, Jennifer R Owen, Steven Zeisel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Torbjörn K Nilsson*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA torbjorn.nilsson@umu.se.
Anita Hurtig-Wennlöf*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Michael Sjöström*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Wolfgang Herrmann*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Rima Obeid*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer R Owen*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Steven Zeisel*Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health, School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany; Nutrition Research Institute, University of North Carolina, Chapel Hill, Kannapolis, North Carolina, USA; and Department of Nutrition, University of North Carolina Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Saarland University · DEDavid H. Murdock Research Institute · USKarolinska Institutet · SEÖrebro University · SEUmeå University · SEUniversity of North Carolina at Chapel Hill · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
NIDDK NIH HHS DK56350
6 · The paper itself

Abstract

Academic achievement in adolescents is correlated with 1-carbon metabolism (1-CM), as folate intake is positively related and total plasma homocysteine (tHcy) negatively related to academic success. Because another 1-CM nutrient, choline is essential for fetal neurocognitive development, we hypothesized that choline and betaine could also be positively related to academic achievement in adolescents. In a sample of 15-yr-old children (n= 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamineN-methyltransferase (PEMT), rs12325817 (G>C). The sum of school grades in 17 major subjects was used as an outcome measure for academic achievement. Lifestyle and family socioeconomic status (SES) data were obtained from questionnaires. Plasma choline was significantly and positively associated with academic achievement independent of SES factors (paternal education and income, maternal education and income, smoking, school) and of folate intake (P= 0.009,R(2)= 0.285). With the addition of thePEMTrs12325817 polymorphism, the association value was only marginally changed. Plasma betaine concentration, tHcy, and theMTHFR677C>T polymorphism did not affect academic achievement in any tested model involving choline. Dietary intake of choline is marginal in many adolescents and may be a public health concern.-Nilsson, T. K., Hurtig-Wennlöf, A., Sjöström, M., Herrmann, W., Obeid, R., Owen, J. R., Zeisel, S. Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.

Indexed as

Educational StatusAdolescentBetaineCholineCross-Sectional StudiesFemaleGenotypeHomocysteineHumansLinear ModelsMaleMethylenetetrahydrofolate Reductase (NADPH2)Phosphatidylethanolamine N-MethyltransferasePolymorphism, Single NucleotideSocial ClassSurveys and QuestionnairesBetaineCholineHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanPEMT protein, humanPhosphatidylethanolamine N-Methyltransferasebetainecholinefolateschool grades

Identifiers

PMID26728177
PMCPMC4799502
OpenAlexW2224799750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.