ArticleBMC plant biology2016
Reduced expression of AtNUP62 nucleoporin gene affects auxin response in Arabidopsis.
Article in BMC plant biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
- Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells.The EMBO journal · 2026Article
- The role of phase separation for RNA and protein transport through the nuclear pore complex.Journal of experimental botany · 2026Review
- The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection.Nature communications · 2025Article
- MdNup62 involved in salt and osmotic stress tolerance in apple.Scientific reports · 2023Article
- CPR5-mediated nucleo-cytoplasmic localization of IAA12 and IAA19 controls lateral root development during abiotic stress.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- MdNup62 interactions with MdHSFs involved in flowering and heat-stress tolerance in apple.BMC plant biology · 2022Article
- Function of Nuclear Pore Complexes in Regulation of Plant Defense Signaling.International journal of molecular sciences · 2022Review
- MdNup54 Interactions With MdHSP70 Involved in Flowering in Apple.Frontiers in plant science · 2022Article
- SDG2 regulates Arabidopsis inflorescence architecture through SWR1-ERECTA signaling pathway.iScience · 2021Article
- Genome-wide association studies of fruit quality traits in jujube germplasm collections using genotyping-by-sequencing.The plant genome · 2020Article
- Genomic identification and expression analysis of nuclear pore proteins in Malus domestica.Scientific reports · 2020Article
- Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis.The Plant cell · 2020Article
- Polysaccharide Fraction Extracted from Endophytic FungusBiomolecules · 2019Article
- The Arabidopsis nucleoporin NUP1 is essential for megasporogenesis and early stages of pollen development.Plant cell reports · 2019Article
- The Nup98 Homolog APIP12 Targeted by the Effector AvrPiz-t is Involved in Rice Basal Resistance Against Magnaporthe oryzae.Rice (New York, N.Y.) · 2017Article
- Nup82 functions redundantly with Nup136 in a salicylic acid-dependent defense response of Arabidopsis thaliana.Nucleus (Austin, Tex.) · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe plant nuclear pore complex has strongly attracted the attention of the scientific community during the past few years, in particular because of its involvement in hormonal and pathogen/symbiotic signalling. In Arabidopsis thaliana, more than 30 nucleoporins have been identified, but only a few of them have been characterized. Among these, AtNUP160, AtNUP96, AtNUP58, and AtTPR have been reported to modulate auxin signalling, since corresponding mutants are suppressors of the auxin resistance conferred by the axr1 (auxin-resistant) mutation. The present work is focused on AtNUP62, which is essential for embryo and plant development. This protein is one of the three nucleoporins (with AtNUP54 and AtNUP58) of the central channel of the nuclear pore complex.
resultsAtNUP62 promoter activity was detected in many organs, and particularly in the embryo sac, young germinating seedlings and at the adult stage in stipules of cauline leaves. The atnup62-1 mutant, harbouring a T-DNA insertion in intron 5, was identified as a knock-down mutant. It displayed developmental phenotypes that suggested defects in auxin transport or responsiveness. Atnup62 mutant plantlets were found to be hypersensitive to auxin, at the cotyledon and root levels. The phenotype of the AtNUP62-GFP overexpressing line further supported the existence of a link between AtNUP62 and auxin signalling. Furthermore, the atnup62 mutation led to an increase in the activity of the DR5 auxin-responsive promoter, and suppressed the auxin-resistant root growth and leaf serration phenotypes of the axr1 mutant.
conclusionAtNUP62 appears to be a major negative regulator of auxin signalling. Auxin hypersensitivity of the atnup62 mutant, reminding that of atnup58 (and not observed with other nucleoporin mutants), is in agreement with the reported interaction between AtNUP62 and AtNUP58 proteins, and suggests closely related functions. The effect of AtNUP62 on auxin signalling likely occurs in relation to scaffold proteins of the nuclear pore complex (AtNUP160, AtNUP96 and AtTPR).
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