Evidence map›Paper›PMID 26727910›Full record

ArticleJournal of neurovirology2016

Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals.

Kate M Crossley, Shruti Agnihotri, Joga Chaganti, Michael L Rodriguez, Leon Patrick McNally, Nagagopal Venna, Sarah E Turbett, Matthew Gutman, Adrienne Morey, Igor J Koralnik and 1 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kate M CrossleyDepartment of Neurology, St Vincent's Hospital, Level 4 Xavier Building, Sydney, 2010, Australia. kate.crossley@health.nsw.gov.au.ORCID 0000-0003-0553-1903
Shruti AgnihotriDivision of Neuro Immunology, Center for Virology and Vaccine Research, Beth Deaconess Medical Center, Boston, USA.
Joga ChagantiDepartment of Radiology, St Vincent's Hospital, Sydney, Australia.
Michael L RodriguezDepartment of Neuropathology, St Vincent's Hospital, Sydney, Australia.
Leon Patrick McNallyDepartment of Molecular Medicine, St Vincent's Hospital, Sydney, Australia.
Nagagopal VennaDepartment of Neurology, Massachusetts General Hospital, Boston, USA.
Sarah E TurbettDepartment of Infectious Diseases, Massachusetts General Hospital, Boston, USA.
Matthew GutmanDepartment of Neurosurgery, St Vincent's Hospital, Sydney, Australia.
Adrienne MoreyDepartment of Anatomical Pathology, St Vincent's Hospital, Sydney, Australia.
Igor J KoralnikDivision of Neuro Immunology, Center for Virology and Vaccine Research, Beth Deaconess Medical Center, Boston, USA.
Bruce J BrewDepartment of Neurology, St Vincent's Hospital, Sydney Australia, also Peter Duncan Neurosciences Unit Neurosciences Program, St Vincent's Centre for Applied Medical Research, Sydney, Australia.
St Vincent's Hospital Sydney · AUBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USSt Vincent's Hospital Melbourne · AU

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS074995
6 · The paper itself

Abstract

We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

Indexed as

Anti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesCoinfectionFemaleHIV-1HIV InfectionsHumansJC VirusLeukoencephalopathy, Progressive MultifocalMaleMiddle AgedNatalizumabRecurrenceAnti-HIV AgentsNatalizumabNeuroimmunologyNeurovirologyProgressive multifocal leukoencephalopathy

Identifiers

PMID26727910
PMCPMC4925684
OpenAlexW2230158291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.