Evidence map›Paper›PMID 26727887›Full record

ArticleAging2015

Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality.

Mahya Faghih, Sayed M Hosseini, Barbara Smith, Amir Mehdi Ansari, Frank Lay, Ali Karim Ahmed, Tedashi Inagami, Guy P Marti, John W Harmon, Jeremy D Walston and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. The ATMolecules (Basel, Switzerland) · 2023
    Review
  7. The Angiotensin ATPharmacological reviews · 2022
    Review
  8. Article
  9. Valsartan nano-filaments alter mitochondrial energetics and promote faster healing in diabetic rat wounds.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021
    Article
  10. Targeting the renin-angiotensin-aldosterone system in fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020
    Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mahya FaghihDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Sayed M HosseiniDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Barbara SmithCell Biology Imaging Facility, Johns Hopkins University School of Medicine Baltimore, MD 21224, USA.
Amir Mehdi AnsariDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Frank LayDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Ali Karim AhmedDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Tedashi InagamiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Guy P MartiDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
John W HarmonDepartment of Surgery and Hendrix Burn/Wound Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Jeremy D WalstonDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Peter M AbadirDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USVanderbilt University · US

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Angiotensin Receptor AT1 in Vascular Cell Control.R37HL058205 · NHLBI · VANDERBILT UNIVERSITY · PI INAGAMI, TADASHI · 2001 to 2010
$3.6M
Age Related Change in Mitochondrial Angiotensin System and Mitochondrial DeclineR01AG046441 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2014 to 2018
$2.3M
AGE RELATED CHANGE IN ANGIOTENSIN RECEPTORS AND ITS ROLE IN CHRONIC INFLAMMATIONK23AG035005 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2010 to 2014
$807k
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
Novel Formulation of Topical Losartan for Treatment of Wounds in AgingR21AG043284 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M., WALSTON, JEREMY D · 2013 to 2014
$446k
ANGIOTENSIN RECEPTOR AT1 IN VASCULAR CELL CONTROLR01HL058205 · NHLBI · VANDERBILT UNIVERSITY · PI INAGAMI, TADASHI · 1997 to 2000
$437k
NHLBI NIH HHS HL58205NHLBI NIH HHS R01 HL058205NHLBI NIH HHS R37 HL058205NIA NIH HHS 1R01AG046441NIA NIH HHS K23 AG035005NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG046441NIA NIH HHS R21 AG043284NIA NIH HHS R21AG043284NIH HHS S10 OD016374
6 · The paper itself

Abstract

Wounds are among the most common, painful, debilitating and costly conditions in older adults. Disruption of the angiotensin type 1 receptors (AT1R), has been associated with impaired wound healing, suggesting a critical role for AT1R in this repair process. Biological functions of angiotensin type 2 receptors (AT2R) are less studied. We investigated effects of genetically disrupting AT2R on rate and quality of wound healing. Our results suggest that AT2R effects on rate of wound closure depends on the phase of wound healing. We observed delayed healing during early phase of wound healing (inflammation). An accelerated healing rate was seen during later stages (proliferation and remodeling). By day 12, fifty percent of AT2R(-/-) mice had complete wound closure as compared to none in either C57/BL6 or AT1R(-/-) mice. There was a significant increase in AT1R, TGFβ1 and TGFβ2 expression during the proliferative and remodeling phases in AT2R(-/-) mice. Despite the accelerated closure rate, AT2R(-/-) mice had more fragile healed skin. Our results suggest that in the absence of AT2R, wound healing rate is accelerated, but yielded worse skin quality. Elucidating the contribution of both of the angiotensin receptors may help fine tune future intervention aimed at wound repair in older individuals.

Indexed as

AnimalsGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Transforming Growth Factor alphaTransforming Growth Factor betaWound HealingReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2Transforming Growth Factor alphaTransforming Growth Factor betaAngiotensinAT1RAT2RTGF

Identifiers

PMID26727887
PMCPMC4712341
OpenAlexW2323869649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.