ArticleFunctional neurology
Cortical excitability changes over time in progressive multiple sclerosis.
Article in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Brain stimulation for patients with multiple sclerosis: an umbrella review of therapeutic efficacy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Gait instability is a more specific predictor of corticospinal tract function than gait speed in clinically stable multiple sclerosis.Scientific reports · 2025Article
- The corticospinal tract in multiple sclerosis: correlation between cortical excitability and magnetic resonance imaging measures.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Article
- Links between Neuroanatomy and Neurophysiology with Turning Performance in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Article
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- The importance of pyramidal tract integrity for cortical plasticity and related functionality in patients with multiple sclerosis.Frontiers in neurology · 2023Article
- Neurophysiological and behavioural correlates of ocrelizumab therapy on manual dexterity in patients with primary progressive multiple sclerosis.Journal of neurology · 2022Article
- High Estrogen Levels Cause Greater Leg Muscle Fatigability in Eumenorrheic Young Women after 4 mA Transcranial Direct Current Stimulation.Brain sciences · 2022Article
- A comprehensive review of transcranial magnetic stimulation in secondary dementia.Frontiers in aging neuroscience · 2022Review
- The Upper Motor Neuron-Improved Knowledge from ALS and Related Clinical Disorders.Brain sciences · 2021Review
- Myelination- and immune-mediated MR-based brain network correlates.Journal of neuroinflammation · 2020Article
- Walking Training Enhances Corticospinal Excitability in Progressive Multiple Sclerosis-A Pilot Study.Frontiers in neurology · 2020Article
- Inflammation and Corticospinal Functioning in Multiple Sclerosis: A TMS Perspective.Frontiers in neurology · 2020Article
- Validation of Quantitative Scores Derived From Motor Evoked Potentials in the Assessment of Primary Progressive Multiple Sclerosis: A Longitudinal Study.Frontiers in neurology · 2020Article
- Cortical Excitability Measures May Predict Clinical Response to Fampridine in Patients with Multiple Sclerosis and Gait Impairment.Brain sciences · 2019Article
- Relationships between the integrity and function of lumbar nerve roots as assessed by diffusion tensor imaging and neurophysiology.Neuroradiology · 2017Article
- The Role of Transcranial Magnetic Stimulation as a Surrogate Marker of Disease Activity in Patients with Multiple Sclerosis: A Literature Review.Innovations in clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 25 patients with progressive forms of multiple sclerosis (MS), motor cortex excitability was longitudinally studied over one year by means of transcranial magnetic stimulation (TMS). The following TMS parameters were considered: resting and active motor thresholds (MTs), input-output curve, short-interval intracortical inhibition (SICI), and intracortical facilitation. Clinical evaluation was based on the Expanded Disability Status Scale (EDSS). In the 16 patients not receiving disease-modifying drugs, the EDSS score worsened, resting MT increased, and SICI decreased. By contrast, no clinical for neurophysiological changes were found over time in the nine patients receiving immunomodulatory therapy. The natural course of progressive MS appears to be associated with a decline in cortical excitability of both pyramidal neurons and inhibitory circuits. This pilot study based on a small sample suggests that disease-modifying drugs may allow cortical excitability to remain stable, even in patients with progressive MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.