Evidence map›Paper›PMID 26727703›Full record

ArticleFunctional neurology

Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis.

Eloy Roura, Torben Schneider, Marc Modat, Pankaj Daga, Nils Muhlert, Declan Chard, Sebastien Ourselin, Xavier Lladó, Claudia Gandini Wheeler-Kingshott

Abstract read
In one paragraph

Article in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eloy Roura
Torben Schneider
Marc Modat
Pankaj Daga
Nils Muhlert
Declan Chard
Sebastien Ourselin
Xavier Lladó
Claudia Gandini Wheeler-Kingshott

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Co-registration of structural T1-weighted (T1w) scans and diffusion tensor imaging (DTI)-derived fractional anisotropy (FA) maps to a common space is of particular interest in neuroimaging, as T1w scans can be used for brain segmentation while DTI can provide microstructural tissue information. While the effect of lesions on registration has been tackled and solutions are available, the issue of atrophy is still open to discussion. Multi-channel (MC) registration algorithms have the advantage of maintaining anatomical correspondence between different contrast images after registration to any target space. In this work, we test the performance of an MC registration approach applied to T1w and FA data using simulated brain atrophy images. Experimental results are compared with a standard single-channel registration approach. Multi-channel registration of fractional anisotropy and T1-weighted images in the presence of atrophy: application to multiple sclerosis Both qualitative and quantitative evaluations are presented, showing that the MC approach provides better alignment with the target while maintaining better T1w and FA co-alignment.

Indexed as

AlgorithmsDiffusion Magnetic Resonance ImagingAdultAnisotropyAtrophyBrainDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedMultiple SclerosisSensitivity and Specificity

Identifiers

PMID26727703
PMCPMC4758777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.