Evidence map›Paper›PMID 26727524›Full record

ArticleAlcoholism, clinical and experimental research2016

Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.

Cassandra A Slater, Asti Jackson, Pretal P Muldoon, Anton Dawson, Megan O'Brien, Lindsey G Soll, Rehab Abdullah, F Ivy Carroll, Andrew R Tapper, Michael F Miles and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Promoting activity of (α4)Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Cassandra A SlaterDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Asti JacksonDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Pretal P MuldoonDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Anton DawsonDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Megan O'BrienDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Lindsey G SollBrudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts.
Rehab AbdullahDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
F Ivy CarrollCenter for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, North Carolina.
Andrew R TapperBrudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts.
Michael F MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Matthew L BanksDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Jill C BettingerDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Imad M DamajDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Virginia Commonwealth University · USNeuropsychiatric Research Institute · USTriangle · USUniversity of Massachusetts Chan Medical School · US

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JILL C BETTINGER · 2014 to 2026
$19.6M
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
Neuronal nicotinic acetylcholine receptors and the response to alcoholR01AA017656 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TAPPER, ANDREW R · 2009 to 2018
$3.7M
Genes and molecular pathways in nicotine dependence and withdrawalR01DA032246 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DAMAJ, M. IMAD, MILES, MICHAEL F · 2013 to 2017
$1.7M
NIAAA NIH HHS P50 AA022537NIAAA NIH HHS P50AA022537NIAAA NIH HHS R01 AA017656NIDA NIH HHS DA-DA032246NIDA NIH HHS R01 DA032246NIDA NIH HHS T32 DA007027
6 · The paper itself

Abstract

backgroundEthanol (EtOH) and nicotine abuse are 2 leading causes of preventable mortality in the world, but little is known about the pharmacological mechanisms mediating co-abuse. Few studies have examined the interaction of the acute effects of EtOH and nicotine. Here, we examine the effects of nicotine administration on the duration of EtOH-induced loss of righting reflex (LORR) and characterize the nature of their pharmacological interactions in C57BL/6J mice.

methodsWe assessed the effects of EtOH and nicotine and the nature of their interaction in the LORR test using isobolographic analysis after acute injection in C57BL/6J male mice. Next, we examined the importance of receptor efficacy using nicotinic partial agonists varenicline and sazetidine. We evaluated the involvement of major nicotinic acetylcholine receptor (nAChR) subtypes using nicotinic antagonist mecamylamine and nicotinic α4- and α7-knockout mice. The selectivity of nicotine's actions on EtOH-induced LORR was examined by testing nicotine's effects on the hypnotic properties of ketamine and pentobarbital. We also assessed the development of tolerance after repeated nicotine exposure. Last, we assessed whether the effects of nicotine on EtOH-induced LORR extend to hypothermia and EtOH intake in the drinking in the dark (DID) paradigm.

resultsWe found that acute nicotine injection enhances EtOH's hypnotic effects in a synergistic manner and that receptor efficacy plays an important role in this interaction. Furthermore, tolerance developed to the enhancement of EtOH's hypnotic effects by nicotine after repeated exposure of the drug. α4* and α7 nAChRs seem to play an important role in nicotine-EtOH interaction in the LORR test. In addition, the magnitude of EtOH-induced LORR enhancement by nicotine was more pronounced in C57BL/6J than DBA/2J mice. Furthermore, acute nicotine enhanced ketamine and pentobarbital hypnotic effects in the mouse. Finally, nicotine enhanced EtOH-induced hypothermia but decreased EtOH intake in the DID test.

conclusionsOur results demonstrate that nicotine synergistically enhances EtOH-induced LORR in the mouse.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsAzetidinesBody TemperatureCentral Nervous System DepressantsDrug InteractionsEthanolHypnotics and SedativesHypothermiaKetamineMecamylamineMiceMice, Inbred C57BLMice, Inbred DBAMice, KnockoutNicotinealpha7 Nicotinic Acetylcholine ReceptorAzetidinesCentral Nervous System DepressantsEthanolHypnotics and SedativesKetamineMecamylamineNicotineNicotinic AgonistsNicotinic AntagonistsPentobarbitalPyridinesReceptors, Nicotinicsazetidine-AVareniclineEthanolLoss of Righting ReflexMiceNicotine

Identifiers

PMID26727524
PMCPMC4700556
OpenAlexW2211194459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.