Evidence map›Paper›PMID 26727410›Full record

Trial reportJournal of consulting and clinical psychology2016

In cognitive therapy for depression, early focus on maladaptive beliefs may be especially efficacious for patients with personality disorders.

John R Keefe, Christian A Webb, Robert J DeRubeis

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of consulting and clinical psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Psychological interventions for antisocial personality disorder.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Psychological therapies for people with borderline personality disorder.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Trial
  4. Article
  5. Observational
  6. The YSQ-R: Predictive Validity and Comparison to the Short and Long Form Young Schema Questionnaire.International journal of environmental research and public health · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pathogenic beliefs among patients with depressive disorders.Neuropsychiatric disease and treatment · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

John R KeefeDepartment of Psychology, University of Pennsylvania.ORCID 0000-0001-7250-8960
Christian A WebbDepartment of Psychiatry, McLean Hospital, Harvard Medical School.
Robert J DeRubeisDepartment of Psychology, University of Pennsylvania.
University of Pennsylvania · USHarvard University · US

Funding

Prevention of Recurrence in Depression with Drugs and CTK02MH001697 · NIMH · VANDERBILT UNIVERSITY · PI HOLLON, STEVEN DENNIS · 2000 to 2009
$1.2M
Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic AdolescentsK23MH108752 · NIMH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2015 to 2018
$703k
COGNITIVE THERAPY AND PHARMACOTHERAPY FOR DEPRESSIONR10MH055875 · NIMH · VANDERBILT UNIVERSITY · PI HOLLON, STEVEN D · 1996 to 2000
$231k
Investigating Neural and Psychotherapeutic Mediators of Placebo Response in MDDF32MH099801 · NIMH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2012 to 2015
$139k
NIMH NIH HHS F32 MH099801NIMH NIH HHS K02 MH001697NIMH NIH HHS K23 MH108752NIMH NIH HHS MH01697NIMH NIH HHS MH50129NIMH NIH HHS R10 MH055875
6 · The paper itself

Abstract

objectivePatients with major depressive disorder (MDD) and a comorbid personality disorder (PD) have been found to exhibit relatively poor outcomes in cognitive therapy (CT) and other treatments. Adaptations of CT focusing heavily on patients' core beliefs have yielded promising findings in the treatment of PD. However, there have been no investigations that have specifically tested whether increased focus on maladaptive beliefs contributes to CT's efficacy for these patients.

methodCT technique use from an early CT session was assessed for 59 patients (33 without PD, 26 with PD-predominantly Cluster C) who participated in a randomized controlled trial for moderate to severe MDD. Scores were calculated for directive CT techniques (CT-Concrete) and a set of belief-focused items (CT-Belief) as rated by the Collaborative Study Process Rating Scale. Robust regressions were conducted to estimate relations between scores on each of these measures and change in depressive and PD symptoms. A PD status by CT-Belief use interaction tested the hypothesis that therapist use of CT-Belief techniques would exhibit a stronger association with symptom change in the PD group relative to the non-PD group.

resultsAs hypothesized, a significant interaction between PD status and use of CT-Belief techniques emerged in the prediction of depressive and PD symptom change. Among PD patients, higher early CT-Belief interventions were found to predict significantly greater improvement. CT-Belief use did not predict greater symptom change among those without PD.

conclusionsEarly focus on CT-Belief interventions may facilitate changes in depression and PD symptoms for patients with MDD-PD comorbidity.

Indexed as

AdultCognitive Behavioral TherapyComorbidityDepressionFemaleHumansMajor Depressive DisorderMaleMiddle AgedPersonality DisordersSeverity of Illness IndexTreatment Outcome

Identifiers

PMID26727410
PMCPMC4936187
OpenAlexW2323442620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.