ArticleEnvironmental science & technology2016
Placental Metal Concentrations in Relation to Maternal and Infant Toenails in a U.S. Cohort.
Article in Environmental science & technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts.Environment international · 2020Pooled it
- Associations of prenatal metal exposures with autism-related outcomes in the ECHO cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Baseline exposure-response assessment of metals from dried blood spots and personal household air pollution concentrations among pregnant women in Rwanda: household air pollution intervention network trial.Journal of health, population, and nutrition · 2025Article
- Prenatal metal exposures and kidney function in adolescence in Project Viva.Environmental health : a global access science source · 2024Article
- Associations of Perinatal Metal and Metalloid Exposures with Early Child Behavioral Development Over Time in the New Hampshire Birth Cohort Study.Exposure and health · 2024Article
- Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.Exposure and health · 2023Article
- Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age.International journal of molecular sciences · 2023Article
- A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023Review
- Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches.Chemosphere · 2023Article
- Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.Exposure and health · 2023Article
- Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth.Pediatric research · 2023Article
- Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications.International journal of women's health · 2023Article
- Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population.Epigenetics · 2022Article
- Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts.Epigenetics · 2022Observational
- Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy.International journal of molecular sciences · 2022Article
- Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS).Environmental research · 2022Article
- Prenatal exposure to metal mixtures and newborn neurobehavior in the Rhode Island Child Health Study.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh.Environmental health : a global access science source · 2022Article
- Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study.Frontiers in epidemiology · 2022Article
- Placental Gene Transcript Proportions are Altered in the Presence ofFrontiers in genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Metal contaminants cross the placenta, presenting a heightened risk of perturbing fetal development. Information about placental concentrations and transfer of multiple potentially toxic metals from low to moderate exposure is lacking. We measured concentrations of Cd, Pb, Hg, Mn, Se, and Zn in 750 placentas collected from women enrolled in the New Hampshire Birth Cohort Study and examined the correlation between elements, and profiles of potentially toxic metals (Cd, Pb, Hg, and Mn) stratified by nutrient concentrations (Zn and Se) using principal components analyses. We further examined the indirect effects of maternal metal concentrations on infant metal concentrations through placental metal concentrations using structural equation models. Placental metal concentrations were all correlated, particularly Zn and Mn, and Zn and Cd, and the principal component of metals differed by stratum of high versus low Zn and Se. Associations were observed between placenta and maternal toenail Se (β = 63.49; P < 0.0001) and Pb (β = 0.90; P < 0.0001) but not other metals. Structural equation models did not indicate any statistically significant indirect effects through placental metal concentrations. Placental metal concentrations may represent a distinct biomarker of metal exposure and adverse health impacts to the fetus, particularly those stemming from the placenta.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.