ArticlePLoS pathogens2016
A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
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- The glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagicMicrobiology (Reading, England) · 2026Article
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- A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens.PLoS pathogens · 2024Article
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- Distinct ecological fitness factors coordinated by a conservedProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Performance upgrade of a microbial explosives' sensor strain by screening a high throughput saturation library of a transcriptional regulator.Computational and structural biotechnology journal · 2023Article
- Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associatedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Preferential catabolism of l- vs d-serine by Proteus mirabilis contributes to pathogenesis and catheter-associated urinary tract infection.Molecular microbiology · 2022Article
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- The Conserved Serine Transporter SdaC Moonlights To Enable Self Recognition.Journal of bacteriology · 2022Article
- Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver Disease.Frontiers in medicine · 2022Review
- Bacterial metabolism and pathogenesis intimate intertwining: time for metabolic modelling to come into action.Microbial biotechnology · 2022Article
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- Microbial Musings - October 2021.Microbiology (Reading, England) · 2021Article
- Heterogeneity in populations of enterohaemorrhagic Escherichia coli undergoing D-serine adaptation.Current genetics · 2021Review
- Genomic plasticity of pathogenicProceedings of the National Academy of Sciences of the United States of America · 2020Article
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- ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative PathogensAntimicrobial agents and chemotherapy · 2020Article
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9 authors at 5 institutions in 3 countries.
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Abstract
The ability of any organism to sense and respond to challenges presented in the environment is critically important for promoting or restricting colonization of specific sites. Recent work has demonstrated that the host metabolite D-serine has the ability to markedly influence the outcome of infection by repressing the type III secretion system of enterohaemorrhagic Escherichia coli (EHEC) in a concentration-dependent manner. However, exactly how EHEC monitors environmental D-serine is not understood. In this work, we have identified two highly conserved members of the E. coli core genome, encoding an inner membrane transporter and a transcriptional regulator, which collectively help to "sense" levels of D-serine by regulating its uptake from the environment and in turn influencing global gene expression. Both proteins are required for full expression of the type III secretion system and diversely regulated prophage-encoded effector proteins demonstrating an important infection-relevant adaptation of the core genome. We propose that this system acts as a key safety net, sampling the environment for this metabolite, thereby promoting colonization of EHEC to favorable sites within the host.
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