SynthesisScientific reports2016
Parity and gastric cancer risk: a systematic review and dose-response meta-analysis of prospective cohort studies.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses.Frontiers in oncology · 2025Pooled it
- Effect of hyperthermic intraperitoneal chemotherapy for gastric cancer patients: a meta-analysis of the randomized controlled trials.The Journal of international medical research · 2019Pooled it
- Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta-analysis of observational studies.British journal of clinical pharmacology · 2018Pooled it
- Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies.British journal of clinical pharmacology · 2017Pooled it
- Sertraline use in the first trimester and risk of congenital anomalies: a systemic review and meta-analysis of cohort studies.British journal of clinical pharmacology · 2017Pooled it
- Use of selective serotonin-reuptake inhibitors in the first trimester and risk of cardiovascular-related malformations: a meta-analysis of cohort studies.Scientific reports · 2017Pooled it
- Effects of Reproductive Factors on Lauren Intestinal-Type Gastric Cancers in Females: A Multicenter Retrospective Study in South Korea.Gut and liver · 2022Article
- Gastroesophageal Cancer During Pregnancy: a Case Report and Review of the Literature.Journal of gastrointestinal cancer · 2019Review
- Article
- Cancer: A disease at the crossroads of trade-offs.Evolutionary applications · 2017Article
- Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We performed this meta-analysis of epidemiological studies to comprehensively assess the association between parity and gastric cancer risk, because previous studies have shown conflicting results regarding this topic. Relevant prospective studies were identified by searching the following databases: PubMed, EMBASE, and Web of Science, and random-effects models were used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs). Our search yielded 10 prospective cohort studies involving a total of 6624 gastric cancer cases and 5,559,695 non-cases. The SRRs for ever parity vs. nulliparous and highest vs. lowest parity number were 0.96 (95%CI = 0.87-1.05, I(2) = 0%) and 1.03 (95%CI = 0.94-1.13, I(2) = 0%), respectively. Additionally, the SRR for an increment of one live birth was 1.00 (95%CI = 0.97-1.03, I(2) = 18.6%). These non-significant associations were observed in all subgroups as stratified by the number of gastric cases, follow-up years, geographic location, menopausal status, anatomic subsite of gastric cancer, and adjustment for potential confounders, as well as in sensitivity analyses. Our meta-analysis found no significant association between parity and gastric cancer risk. However, further studies should be conducted to validate our findings and could provide more detailed results by stratifying their findings by Lauren's subtype, histology, and anatomic site, as well as fully adjusting for potential confounding factors.
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