ArticlePloS one2016
Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Article
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- Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird.Molecular ecology · 2026Article
- Sperm DNA Fragmentation in Normozoospermic Men Is Associated with Blastocyst Formation and Quality in Conventional In Vitro Fertilization.Journal of clinical medicine · 2025Article
- Intra-individual variability of the human seminal plasma metabolome.Asian journal of andrology · 2025Article
- Raw and boiled ginger (Zingiber officinale Roscoe) inclusive diet improves fertility parameters in high cholesterol diet-induced obese rats.BMC complementary medicine and therapies · 2025Article
- Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review).Molecular medicine reports · 2025Review
- Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active.Journal of extracellular vesicles · 2025Article
- Elevated Lipid Concentrations in Seminal Plasma Can Reduce Sperm Motility in Simmental Bulls.Animals : an open access journal from MDPI · 2025Article
- Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes.Frontiers in immunology · 2025Article
- Article
- Lipids, lipid-modified drug target genes, and the risk of male infertility: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Exploring correlations: Human seminal plasma and blood serum biochemistry in relation to semen quality.PloS one · 2024Article
- Lipidomic Profile of Human Sperm Membrane Identifies a Clustering of Lipids Associated with Semen Quality and Function.International journal of molecular sciences · 2023Article
- Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice.Scientific reports · 2023Article
- How much obesity and diabetes do impair male fertility?Reproductive biology and endocrinology : RB&E · 2023Article
- Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments.International journal of molecular sciences · 2022Article
- Alginate oligosaccharides increase boar semen quality by affecting gut microbiota and metabolites in blood and sperm.Frontiers in microbiology · 2022Article
- House feeding pattern increased male yak fertility by improving gut microbiota and serum metabolites.Frontiers in veterinary science · 2022Article
- Fertility-associated biochemical components in seminal plasma and serum of buffalo (Frontiers in veterinary science · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis prospective study was designed to investigate the relationship between lipids levels in both serum and seminal plasma and semen parameters.
methods631 subfertile men were enrolled. Their obesity-associated markers were measured, and semen parameters were analyzed. Also, seminal plasma and serum TC, TG, HDL and LDL and serum FFA, FSH, LH, total testosterone (TT), estradiol (E2) and SHBG levels were detected.
resultsSeminal plasma and serum TG, TC and LDL levels were positively related to age. Serum TC, TG and LDL were positively related to obesity-associated markers (P < 0.001), while only seminal plasma TG was positively related to them (P < 0.05). For lipids levels in serum and seminal plasma, only TG level had slightly positive correlation between them (r = 0.081, P = 0.042). There was no significant correlation between serum lipids levels and semen parameters. However, seminal plasma TG, TC, LDL and HDL levels were negatively related to one or several semen parameters, including semen volume (SV), sperm concentration (SC), total sperm count (TSC), sperm motility, progressive motility (PR) and total normal-progressively motile sperm counts (TNPMS). Moreover, seminal plasma TG, TC, LDL and HDL levels in patients with oligospermatism, asthenospermia and teratozoospermia were higher than those with normal sperm concentration, motility or morphology. After adjusting age and serum LH, FSH, TT, E2 and SHBG levels, linear regression analysis showed that SV was still significantly correlated with seminal plasma LDL (P = 0.012), both of SC and TSC with seminal plasma HDL (P = 0.028 and 0.002), and both of PR and sperm motility with seminal plasma TC (P = 0.012 and 0.051).
conclusionThe abnormal metabolism of lipids in male reproductive system may contribute to male factor infertility.
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