Evidence map›Paper›PMID 26726316›Full record

ArticleJournal of heart and cardiology

Impaired Coronary Endothelial Vasorelaxation in a Preclinical Model of Peripheral Arterial Insufficiency.

A A Arce-Esquivel, A K Bunker, G H Simmons, H T Yang, M H Laughlin, R L Terjung

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of heart and cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A A Arce-EsquivelDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri ; Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, Texas.
A K BunkerMorningside College, Sioux City, Iowa.
G H SimmonsDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.
H T YangDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.
M H LaughlinDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri ; Department of Medical Pharmacology and Physiology, College of Medicine, University of Missouri, Columbia, Missouri ; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
R L TerjungDepartment of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri ; Department of Medical Pharmacology and Physiology, College of Medicine, University of Missouri, Columbia, Missouri ; Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
The University of Texas at Tyler · US

Funding

TRAINING: MUSCLE BLOOD FLOW &CAPILLARY DYNAMICSR01HL036088 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LAUGHLIN, M HAROLD · 1985 to 2013
$4.0M
Exercise &Health: Integration from Molecule to PatientT32AR048523 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI TERJUNG, RONALD L · 2003 to 2013
$2.5M
NHLBI NIH HHS R01 HL036088NIAMS NIH HHS T32 AR048523
6 · The paper itself

Abstract

The present study was designed to determine whether adult swine with peripheral artery insufficiency (PAI) would exhibit vascular dysfunction in vessels distinct from the affected distal limbs, the coronary conduit arteries. Moreover, we sought to evaluate the effect of exercise training on coronary vasomotor function in PAI. Eighteen female healthy young Yucatan miniature swine were randomly assigned to either occluded exercise trained (Occl-Ex, n=7), or occluded-sedentary (Occl-Sed, n=5), or non-occluded, non-exercised control (Non-Occl-Con, n=6) groups. Occl-Ex pigs were progressively trained by running on a treadmill (5days/week, 12 weeks). The left descending artery (LAD) and left circumflex (LCX) coronary arteries were harvested. Vasorelaxation to adenosine diphosphate (ADP), bradykinin (BK), and sodium nitro-prusside (SNP) were assessed in LAD's; while constrictor responses to phenylephrine (PE), angiotensin II (Ang II), and endothelin-1 (ET-1) were assessed in LCX's. Vasorelaxation to ADP was reduced in LADs from Occl-Sed and Occl-Ex pigs (

Indexed as

Coronary dysfunctionExerciseMiniature swinePeripheral artery disease

Identifiers

PMID26726316
PMCPMC4696773
OpenAlexW2283230010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.